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Income Taxes (Details)	9 Months Ended	12 Months Ended
	Sep. 30, 2018	Dec. 31, 2017
Income Tax Disclosure [Abstract]
Income tax benefit at federal statutory rate	(21.00%)	(34.00%)
State income tax, net of federal benefit	(7.70%)	(6.50%)
Warrant expense	9.40%	10.60%
Disqualified interest and other	1.00%	0.90%
Research credits	(1.50%)	(1.20%)
U.S. tax reform		8.30%
Valuation allowance	19.80%	21.90%
Effective tax rate

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) attributable to Research credits.

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Percentage of federal tax reform.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) attributable to warrant expense.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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