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Accrued Expenses (Tables)
 9 Months Ended
Sep. 30, 2018
Accrued Expenses [Abstract]  
Schedule of accrued expenses
  2018  2017 
Accrued license fees $65,000  $120,000 
Legal costs  833,470   553,037 
Accrued issuance costs  204,000   28,083 
Accrued payroll  276,639   223,195 
Advances  —   50,000 
Other  211,913   47,302 
  $1,591,022  $1,021,617