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Income Taxes (Details) | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2018 | Dec. 31, 2017
Income Tax Disclosure [Abstract] |  |
Income tax benefit at federal statutory rate | (21.00%) | (34.00%)
State income tax, net of federal benefit | (7.70%) | (6.50%)
Warrant expense | 9.40% | 10.60%
Disqualified interest and other | 1.00% | 0.90%
Research credits | (1.50%) | (1.20%)
U.S. tax reform |  | 8.30%
Valuation allowance | 19.80% | 21.90%
Effective tax rate |  |

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