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Condensed Consolidated Statements of Changes in Stockholders' Equity (Deficit) (Unaudited) - USD ($) | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Total
--- | --- | --- | --- | ---
Balance at Dec. 31, 2016 | $ 31 | $ 119 | $ (266,370) | $ (266,220)
Balance, shares at Dec. 31, 2016 | 5,216,565 |  |  |
Issuance of stock in connection with intellectual license agreement | $ 860 | 22,555 |  | 23,415
Issuance of stock in connection with intellectual license agreement, shares | 859,976 |  |  |
Issuance of restricted stock award | $ 215 | 7,005 |  | 7,220
Issuance of restricted stock award, shares | 215,453 |  |  |
Transfer of shares in connection with merger | $ 1,573 | (1,573) |  |
Transfer of shares in connection with merger, shares | 1,573,000 |  |  |
Par value change in connection with merger | $ 5,186 | (5,186) |  |
Stock-based compensation |  | 69,574 |  | 69,574
Issuance of warrants |  | 61,496 |  | 61,496
Issuance of additional warrants in connection with short-term notes modification |  | 117,280 |  | 117,280
Forgiveness of subscription receivable |  | 9,050 |  | 9,050
Net loss |  |  | (5,058,426) | (5,058,426)
Balance at Dec. 31, 2017 | $ 7,865 | 280,320 | (5,324,796) | (5,036,611)
Balance, shares at Dec. 31, 2017 | 7,864,994 |  |  |
Balance at Sep. 30, 2017 | $ 7,865 | 162,741 | (3,699,438) | (3,528,832)
Balance, shares at Sep. 30, 2017 | 7,864,994 |  |  |
Issuance of stock in connection with intellectual license agreement |  | 299 |  | 299
Issuance of additional warrants in connection with short-term notes modification |  | 117,280 |  | 117,280
Net loss |  |  | (1,625,358) | (1,625,358)
Balance at Dec. 31, 2017 | $ 7,865 | 280,320 | (5,324,796) | (5,036,611)
Balance, shares at Dec. 31, 2017 | 7,864,994 |  |  |
Warrant value adjustment related to short-term note modification |  | (1,170) |  | (1,170)
Net loss |  |  | (1,356,774) | (1,356,774)
Balance at Mar. 31, 2018 | $ 7,865 | 279,150 | (6,681,570) | (6,394,555)
Balance, shares at Mar. 31, 2018 | 7,864,994 |  |  |
Balance at Dec. 31, 2017 | $ 7,865 | 280,320 | (5,324,796) | (5,036,611)
Balance, shares at Dec. 31, 2017 | 7,864,994 |  |  |
Issuance of common stock upon short term notes and convertible notes extinguishments | $ 1,147 | 2,348,790 |  | 2,349,937
Issuance of common stock upon short term notes and convertible notes extinguishments, shares | 1,146,311 |  |  |
Issuance of warrants and reclassification of warrant liability in connection with short-term notes and convertible notes extinguishments |  | 2,008,796 |  | 2,008,796
Issuance of common stock under 2018 private placement | $ 445 | 824,449 |  | 824,894
Issuance of common stock under 2018 private placement, shares | 445,200 |  |  |
Issuance of common stock for consulting services | $ 200 | 469,300 |  | 469,500
Issuance of common stock for consulting services, shares | 200,000 |  |  |
Stock-based compensation |  | 5,467 |  | 5,467
Issuance of warrants under 2019 private placements |  | 288,106 |  | 288,106
Issuance costs related to 2019 and 2018 private placements |  | (173,067) |  | (173,067)
Net loss |  |  | (5,132,914) | (5,132,914)
Balance at Sep. 30, 2018 | $ 9,657 | 6,052,161 | (10,457,710) | (4,395,892)
Balance, shares at Sep. 30, 2018 | 9,656,505 |  |  |
Issuance of common stock for consulting services | $ 50 | 114,950 |  | 115,000
Issuance of common stock for consulting services, shares | 50,000 |  |  |
Issuance of common stock under 2018 and 2019 private placements | $ 330 | 601,319 |  | 601,649
Issuance of common stock under 2018 and 2019 private placements, shares | 330,000 |  |  |
Issuance of warrants under 2018 and 2019 private placements |  | 223,351 |  | 223,351
Issuance costs related to 2018 and 2019 private placements |  | (149,316) |  | (149,316)
Net loss |  |  | (1,352,824) | (1,352,824)
Balance at Dec. 31, 2018 | $ 10,037 | 6,842,465 | (11,810,534) | (4,958,032)
Balance, shares at Dec. 31, 2018 | 10,036,505 |  |  |
Issuance of common stock under 2019 private placement | $ 1,744 | 3,164,640 |  | 3,166,384
Issuance of common stock under 2019 private placement, shares | 1,743,979 |  |  |
Issuance of warrants under 2019 private placements |  | 1,193,564 |  | 1,193,564
Issuance costs related to 2019 and 2018 private placements |  | (698,777) |  | (698,777)
Issuance of common stock upon conversion of convertible promissory notes | $ 839 | 1,920,881 |  | 1,921,720
Issuance of common stock upon conversion of convertible promissory notes, shares | 839,179 |  |  |
Issuance of warrants and reclassification of warrant liability upon conversion of convertible promissory notes |  | 1,565,402 |  | 1,565,402
Share-based compensation - employee |  | 30,085 |  | 30,085
Share-based compensation - non-employee |  | 16,569 |  | 16,569
Exercise of stock options | $ 94 | 3,179 |  | 3,273
Exercise of stock options, shares | 93,555 |  |  |
Exercise of warrants | $ 231 | 416,102 |  | 416,333
Exercise of warrants, shares | 231,296 |  |  |
Net loss |  |  | (2,211,890) | (2,211,890)
Balance at Mar. 31, 2019 | $ 12,945 | $ 14,454,110 | $ (14,022,424) | $ 444,631
Balance, shares at Mar. 31, 2019 | 12,944,514 |  |  |

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