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NeuroOne Medical Technologies Corporation

10901 Red Circle Drive, Suite 150
Minnetonka, MN 54343

February 5, 2019

EDGAR

Division of Corporation Finance

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

	Re:	NeuroOne Medical Technologies Corporation
		Registration Statement on Form S-1
		File No. 333-227265

Ladies and Gentlemen:

Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, NeuroOne Medical Technologies Corporation (the “Company”) respectfully requests that the effective date of the registration statement referred to above be accelerated so that it will become effective at 5:00 p.m., Eastern Time, on February 7, 2019, or as soon thereafter as possible.

The Company hereby acknowledges the following:

· that should the Commission or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing;

· the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and

· the Company may not assert the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

	NeuroOne Medical Technologies Corporation
	By:	/s/ Dave Rosa
	Name:	Dave Rosa
	Title:	Chief Executive Officer