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Income taxes, Statutory to effective tax rate reconciliation (Details)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Effective Tax Rate Reconciliation [Abstract]    
Federal statutory tax rate 21.00% 21.00%
PPP loan forgiveness 0.00% 7.40%
R&D credit 4.30% 7.10%
Stock award excess tax benefit 0.00% 0.30%
State income taxes, net of federal income taxes 1.10% 0.10%
Business meals and entertainment 0.00% (0.20%)
Miscellaneous permanent items 0.00% (0.30%)
Uncertain tax positions (0.50%) (0.40%)
Stock option cancellations (1.90%) (0.60%)
Valuation allowance and tax accruals 1.00% (1.20%)
Other (0.10%) 0.40%
Effective tax rate 24.90% 33.60%