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Statements of Operations - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Statement [Abstract]      
Revenue $ 257,000 $ 257,000 $ 1,256,000
Operating expenses:      
Research and development, net 20,076,000 16,440,000 8,287,000
Selling, general and administrative 7,998,000 12,166,000 7,616,000
Total operating expenses 28,074,000 28,606,000 15,903,000
Loss from operations (27,817,000) (28,349,000) (14,647,000)
Other expense (income):      
Amortization of deferred financing costs and debt discount 100,000 0 755,000
Loss on extinguishment of debt 0 0 1,389,000
Interest income (185,000) 0 0
Interest expense 351,000 (11,000) 48,000
Warrant liability fair value adjustment 1,906,000 0 0
Derivative fair value adjustment 0 0 (10,080,000)
Other expense 0 0 10,000
Total other expense (income): 2,172,000 (11,000) (7,878,000)
Loss from continuing operations before taxes (29,989,000) (28,338,000) (6,769,000)
Income tax benefit 0 0 1,166,000
Loss from continuing operations (29,989,000) (28,338,000) (5,603,000)
(Loss) income from discontinued operations, net of tax expense of $0, $0, and $1,166 for the years ended December 31, 2016, 2015 and 2014, respectively 0 (4,285,000) 1,369,000
Net loss (29,989,000) (32,623,000) (4,234,000)
Deemed dividend for beneficial conversion feature on Series D-2 preferred stock 0 0 (909,000)
Deemed dividend for antidilution adjustments to convertible preferred stock 0 0 (214,000)
Accretion of convertible preferred stock 0 0 (510,000)
Net loss attributable to common stockholders - basic (29,989,000) (32,623,000) (5,867,000)
Derivative fair value adjustment 0 0 (10,080,000)
Net loss attributable to common stockholders - diluted $ (29,989,000) $ (32,623,000) $ (15,947,000)
Net (loss) income per share attributable to common stockholders - basic      
Continuing operations (in dollars per share) $ (1.58) $ (2.33) $ (1.28)
Discontinued operations (in dollars per share) 0.00 (0.35) 0.24
Net loss per share - basic (in dollars per share) (1.58) (2.68) (1.04)
Net (loss) income per share attributable to common stockholders - diluted      
Continuing operations (in dollars per share) (1.58) (2.33) (2.92)
Discontinued operations (in dollars per share) 0.00 (0.35) 0.23
Net loss per share - diluted (in dollars per share) $ (1.58) $ (2.68) $ (2.69)
Weighted average common shares outstanding:      
Basic (in shares) 19,035,299 12,163,559 5,663,311
Diluted (in shares) 19,035,299 12,163,559 5,937,087