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Income Taxes - Income Tax Reconciliation (Details) - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Amount      
Income taxes from continuing operations at statutory rate $ (10,196,000) $ (9,635,000) $ (2,301,000)
State income taxes (1,287,000) (196,000) (471,000)
Stock warrant derivative liability 0 0 (3,427,000)
Stock-based compensation 215,000 15,000 268,000
R&D tax credits (955,000) (1,152,000) (320,000)
Loss on sale of discontinued operations, net of reduction in related valuation allowances 0 (1,458,000) 0
Warrants issuance 730,000 0 0
Other 719,000 (127,000) (190,000)
Increase in valuation allowance 10,774,000 12,553,000 5,275,000
Total income tax benefit $ 0 $ 0 $ (1,166,000)
Percent of Pretax Income      
Income taxes from continuing operations at statutory rate 34.0001% 34.00028% 33.9932%
State income taxes 4.30% 0.70% 7.00%
Stock warrant derivative liability 0.00% 0.00% 50.60%
Stock-based compensation (0.80%) (0.10%) (4.00%)
R&D tax credits 3.20% 4.10% 4.70%
Loss on sale of discontinued operations, net of reduction in related valuation allowances 0.00% 5.10% 0.00%
Warrants issuance (2.40%) 0.00% 0.00%
Other (2.40%) 0.50% 2.80%
Increase in valuation allowance (35.90%) (44.30%) (77.90%)
Total income tax benefit 0.00% 0.00% 17.20%