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Description of Business and Basis of Preparation - Additional Information (Detail) - USD ($) |  |  |  | 3 Months Ended |
--- | --- | --- | --- | --- | ---
Mar. 31, 2020 | Dec. 12, 2019 | Sep. 14, 2018 | Mar. 31, 2020 | Mar. 31, 2019 | Dec. 31, 2019
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Accumulated deficit | $ (278,430,000) |  |  | $ (278,430,000) |  | $ (271,428,000)
Cash and cash equivalents | 20,253,000 |  |  | 20,253,000 |  | 41,920,000
Short-term investments | 14,267,000 |  |  | 14,267,000 |  | $ 6,494,000
Shelf registration maximum equity offering price | $ 127,300,000 |  | $ 175,000,000 |  |  |
Number of warrants issued to purchase common stock (in shares) |  |  | 13,198,075 |  |  |
Aggregate amount receivable upon exercise of warrants |  |  | $ 28,600,000 |  |  |
Warrants, expiration date |  |  | Mar. 14, 2019 |  |  |
Common stock issued, net of expenses |  |  |  | $ 207,000 | $ 2,509,000 |
Option to Purchase Common Stock |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Options expiration date |  | 2020-01 |  |  |  |
Option to Purchase Common Stock | Maximum |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of options not exercised |  | 5,833,333 |  |  |  |
Common Stock |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Common stock issued, net of expenses (in shares) |  |  |  | 285,276 | 2,226,569 |
Common stock issued, net of expenses |  |  |  | $ 1,000 | $ 2,000 |
Sales Agreement | Common Stock |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Shelf registration maximum equity offering price |  |  | $ 25,000,000 |  |  |
June 2016 Public Offering |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of warrants issued to purchase common stock (in shares) |  |  | 4,218,750 |  |  |
Exercise price of warrants (in dollars per share) |  |  | $ 3.00 |  |  |
March 2018 Public Offering | Series 1 Warrant |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of warrants issued to purchase common stock (in shares) |  |  | 13,198,075 |  |  |
Exercise price of warrants (in dollars per share) |  |  | $ 1.85 |  |  |
March 2018 Public Offering | Series 2 Warrant |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of warrants issued to purchase common stock (in shares) |  |  | 7,988,175 |  |  |
Exercise price of warrants (in dollars per share) |  |  | $ 2.00 |  |  |
December 2019 Public Offering |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of warrants issued to purchase common stock (in shares) |  | 38,888,889 |  |  |  |
Common stock issued, net of expenses (in shares) |  | 38,888,889 |  |  |  |
Share price (in dollars per share) |  | $ 0.90 |  |  |  |
Common stock issued, net of expenses |  | $ 32,500,000 |  |  |  |
Underwriters | Maximum |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Option to purchase shares of common stock |  | 5,833,333 |  |  |  |
Underwriters | Warrant liability |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] |  |  |  |  |  |
Number of warrants issued to purchase common stock (in shares) |  | 5,833,333 |  |  |  |
Number of warrants exercised |  | 5,833,333 |  |  |  |

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