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Stockholders' Equity (Tables) | 6 Months Ended
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Jun. 30, 2022
Equity [Abstract] |
Summary of Common Stock Shares Activity | The following table summarizes common stock share activity for the three and six months ended June 30, 2022 and 2021 (dollars in thousands):
|  | Three Months Ended June 30, 2022 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, March 31, 2022 |  |  | 29,221,158 |  |  | $ | 32 |  |  | $ | 403,825 |  |  | $ | (364,930 | ) |  | $ | 38,927 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (13,345 | ) |  |  | (13,345 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 1,100 |  |  |  | — |  |  |  | 1,100 |
Common stock issued, net of expenses |  |  | 3,358,333 |  |  |  | 4 |  |  |  | 18,794 |  |  |  | — |  |  |  | 18,798 |
Common stock issued for vested restricted stock units |  |  | 16,912 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Balance, June 30, 2022 |  |  | 32,596,403 |  |  | $ | 36 |  |  | $ | 423,719 |  |  | $ | (378,275 | ) |  | $ | 45,480 |
|  | Three Months Ended June 30, 2021 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, March 31, 2021 |  |  | 20,625,637 |  |  | $ | 21 |  |  | $ | 357,192 |  |  | $ | (331,289 | ) |  | $ | 25,924 |
Net income |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 1,658 |  |  |  | 1,658 |
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 542 |  |  |  | — |  |  |  | 542 |
Common stock issued, net of expenses |  |  | 2,516,802 |  |  |  | 5 |  |  |  | 3,410 |  |  |  | — |  |  |  | 3,415 |
Common stock issued for vested restricted stock units |  |  | 5,113 |  |  |  | — |  |  |  | 15 |  |  |  | — |  |  |  | 15 |
Vested Loan Agreement warrants |  |  | — |  |  |  | — |  |  |  | 766 |  |  |  | — |  |  |  | 766 |
Balance, June 30, 2021 |  |  | 23,147,552 |  |  | $ | 26 |  |  | $ | 361,925 |  |  | $ | (329,631 | ) |  | $ | 32,320 |
|  | Six Months Ended June 30, 2022 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, December 31, 2021 |  |  | 28,705,334 |  |  | $ | 32 |  |  | $ | 400,705 |  |  | $ | (359,479 | ) |  | $ | 41,258 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (18,796 | ) |  |  | (18,796 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 2,022 |  |  |  | — |  |  |  | 2,022 |
Common stock issued through employee stock purchase plan |  |  | 3,120 |  |  |  | — |  |  |  | 10 |  |  |  | — |  |  |  | 10 |
Common stock issued, net of expesnes |  |  | 3,845,943 |  |  |  | 4 |  |  |  | 20,911 |  |  |  | — |  |  |  | 20,915 |
Common stock issued for vested restricted stock units |  |  | 42,006 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Vested Loan Agreement warrants |  |  | — |  |  |  | — |  |  |  | 71 |  |  |  | — |  |  |  | 71 |
Balance, June 30, 2022 |  |  | 32,596,403 |  |  | $ | 36 |  |  | $ | 423,719 |  |  | $ | (378,275 | ) |  | $ | 45,480 |
|  | Six Months Ended June 30, 2021 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, December 31, 2020 |  |  | 19,663,698 |  |  | $ | 20 |  |  | $ | 349,351 |  |  | $ | (326,613 | ) |  | $ | 22,758 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (3,018 | ) |  |  | (3,018 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 940 |  |  |  | — |  |  |  | 940 |
Common stock issued through employee stock purchase plan |  |  | 2,184 |  |  |  | — |  |  |  | 9 |  |  |  | — |  |  |  | 9 |
Common stock issued, net of expenses |  |  | 2,516,802 |  |  |  | 5 |  |  |  | 3,407 |  |  |  | — |  |  |  | 3,412 |
Common stock issued for conversion of April 2020 Notes |  |  | 959,080 |  |  |  | 1 |  |  |  | 7,452 |  |  |  | — |  |  |  | 7,453 |
Common stock issued for vested restricted stock units |  |  | 5,788 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Vested Loan Agreement warrants |  |  | — |  |  |  | — |  |  |  | 766 |  |  |  | — |  |  |  | 766 |
Balance, June 30, 2021 |  |  | 23,147,552 |  |  | $ | 26 |  |  | $ | 361,925 |  |  | $ | (329,631 | ) |  | $ | 32,320 |
Common Stock Reserved For Future Issuances | The Company had reserved shares of common stock for future issuance as follows:
|  | June 30, 2022 |  |  | December 31, 2021 |
Outstanding stock options |  |  | 2,129,002 |  |  |  | 1,542,126 |
Outstanding restricted stock units |  |  | 1,024,929 |  |  |  | 133,834 |
Warrants to purchase common stock associated with March 2018 public offering – Series 2 |  |  | 798,810 |  |  |  | 798,810 |
Warrants to purchase common stock associated with December 2020 public offering - Series 2 |  |  | 6,800,000 |  |  |  | 6,800,000 |
Prefunded warrants to purchase common stock associated with December 2020 public offering |  |  | 3,200,000 |  |  |  | 3,200,000 |
Warrants to purchase common stock associated with April 2022 Public Offering |  |  | 15,000,000 |  |  |  | — |
Prefunded warrants to purchase common stock associated with April 2022 Public Offering |  |  | 11,666,667 |  |  |  | — |
Warrants to purchase common stock associated with Loan Agreement |  |  | 198,819 |  |  |  | 170,410 |
Warrant to purchase common stock associated with Danforth |  |  | 50,000 |  |  |  | 50,000 |
For possible future issuance for the conversion of the March 2019 Notes |  |  | 1,138,200 |  |  |  | 1,138,200 |
For possible future issuance under 2014 Plan (Note 9) |  |  | 34,206 |  |  |  | 295,220 |
For possible future issuance under employee stock purchase plan |  |  | 3,714 |  |  |  | 3,893 |
For possible future issuance under 2015 Plan (Note 9) |  |  | 124,250 |  |  |  | 235,000 |
Total common shares reserved for future issuance |  |  | 42,168,597 |  |  |  | 14,367,493 |

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