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Stockholders' Equity - Schedule of Reserved Shares of Common Stock for Future Issuance (Detail) - shares | Jun. 30, 2022 | Dec. 31, 2021
--- | --- | ---
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 42,168,597 | 14,367,493
Stock options |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 2,129,002 | 1,542,126
Restricted Stock Units |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 1,024,929 | 133,834
Warrant | March 2018 Public Offering |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 798,810 | 798,810
Warrant | December 2020 Public Offering Series 2 |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 6,800,000 | 6,800,000
Warrant | Prefunded Warrants to Purchase Common Stock Associated with December 2020 Public Offering |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 3,200,000 | 3,200,000
Warrant | Warrants to Purchase Common Stock Associated With April 2022 Public Offering |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 15,000,000 | 0
Warrant | April 2022 Public Offering |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 11,666,667 | 0
Warrant | Warrant to purchase common stock associated with Danforth |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 50,000 | 50,000
Warrant | Warrants to purchase common stock associated with Loan Agreement |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 198,819 | 170,410
March 2019 Notes |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 1,138,200 | 1,138,200
2014 Employee Stock Purchase Plan |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 3,714 | 3,893
2014 Plan |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 34,206 | 295,220
2015 Plan |  |
Class of Stock [Line Items] |  |
Common shares reserved for future issuance | 124,250 | 235,000

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- Definition Aggregate number of common shares reserved for future issuance. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29) -URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 + Details
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