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Stockholders' Equity (Tables) | 9 Months Ended
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Sep. 30, 2022
Equity [Abstract] |
Summary of Common Stock Shares Activity | he following table summarizes common stock share activity for the three and nine months ended September 30, 2022 and 2021 (dollars in thousands):
|  | Three Months Ended September 30, 2022 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, June 30, 2022 |  |  | 32,596,403 |  |  | $ | 36 |  |  | $ | 423,719 |  |  | $ | (378,275 | ) |  | $ | 45,480 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (29,584 | ) |  |  | (29,584 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 1,210 |  |  |  | — |  |  |  | 1,210 |
Common stock issued through employee stock purchase plan |  |  | 3,714 |  |  |  | — |  |  |  | 8 |  |  |  | — |  |  |  | 8 |
Common stock issued, net of expenses |  |  | 50,000 |  |  |  | — |  |  |  | 95 |  |  |  | — |  |  |  | 95 |
Common stock issued for vested restricted stock units |  |  | 6,125 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Balance, September 30, 2022 |  |  | 32,656,242 |  |  | $ | 36 |  |  | $ | 425,032 |  |  | $ | (407,859 | ) |  | $ | 17,209 |
|  | Three Months Ended September 30, 2021 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, June 30, 2021 |  |  | 23,147,552 |  |  | $ | 26 |  |  | $ | 361,925 |  |  | $ | (329,631 | ) |  | $ | 32,320 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (605 | ) |  |  | (605 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 588 |  |  |  | — |  |  |  | 588 |
Common stock issued through employee stock purchase plan |  |  | 2,759 |  |  |  | — |  |  |  | 13 |  |  |  | — |  |  |  | 13 |
Common stock issued, net of expenses |  |  | 733,937 |  |  |  | 1 |  |  |  | 5,300 |  |  |  | — |  |  |  | 5,301 |
Common stock issued for vested restricted stock units |  |  | 1,322 |  |  |  | — |  |  |  | (3 | ) |  |  | — |  |  |  | (3 | )
Balance, September 30, 2021 |  |  | 23,885,570 |  |  | $ | 27 |  |  | $ | 367,823 |  |  | $ | (330,236 | ) |  | $ | 37,614 |
|  | Nine Months Ended September 30, 2022 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, December 31, 2021 |  |  | 28,705,334 |  |  | $ | 32 |  |  | $ | 400,705 |  |  | $ | (359,479 | ) |  | $ | 41,258 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (48,380 | ) |  |  | (48,380 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 3,232 |  |  |  | — |  |  |  | 3,232 |
Common stock issued through employee stock purchase plan |  |  | 6,834 |  |  |  | — |  |  |  | 18 |  |  |  | — |  |  |  | 18 |
Common stock issued, net of expenses |  |  | 3,895,943 |  |  |  | 4 |  |  |  | 21,006 |  |  |  | — |  |  |  | 21,010 |
Common stock issued for vested restricted stock units |  |  | 48,131 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Vested Loan Agreement warrants |  |  | — |  |  |  | — |  |  |  | 71 |  |  |  | — |  |  |  | 71 |
Balance, September 30, 2022 |  |  | 32,656,242 |  |  | $ | 36 |  |  | $ | 425,032 |  |  | $ | (407,859 | ) |  | $ | 17,209 |
|  | Nine Months Ended September 30, 2021 |
|  | Shares of Common Stock |  |  | Common Stock |  |  | Additional Paid-in Capital |  |  | Accumulated Deficit |  |  | Total Stockholders’ Equity |
Balance, December 31, 2020 |  |  | 19,663,698 |  |  | $ | 20 |  |  | $ | 349,351 |  |  | $ | (326,613 | ) |  | $ | 22,758 |
Net loss |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (3,623 | ) |  |  | (3,623 | )
Stock-based compensation expense |  |  | — |  |  |  | — |  |  |  | 1,528 |  |  |  | — |  |  |  | 1,528 |
Common stock issued through employee stock purchase plan |  |  | 4,943 |  |  |  | — |  |  |  | 22 |  |  |  | — |  |  |  | 22 |
Common stock issued, net of expenses |  |  | 3,250,739 |  |  |  | 6 |  |  |  | 8,707 |  |  |  | — |  |  |  | 8,713 |
Common stock issued for conversion of April 2020 Notes |  |  | 959,080 |  |  |  | 1 |  |  |  | 7,452 |  |  |  | — |  |  |  | 7,453 |
Common stock issued for vested restricted stock units |  |  | 7,110 |  |  |  | — |  |  |  | (3 | ) |  |  | — |  |  |  | (3 | )
Vested Loan Agreement warrants |  |  | — |  |  |  | — |  |  |  | 766 |  |  |  | — |  |  |  | 766 |
Balance, September 30, 2021 |  |  | 23,885,570 |  |  | $ | 27 |  |  | $ | 367,823 |  |  | $ | (330,236 | ) |  | $ | 37,614 |
Common Stock Reserved For Future Issuances | The Company had reserved shares of common stock for future issuance as follows:
|  | September 30, 2022 |  |  | December 31, 2021 |
Outstanding stock options |  |  | 2,125,002 |  |  |  | 1,542,126 |
Outstanding restricted stock units |  |  | 990,015 |  |  |  | 133,834 |
Warrants to purchase common stock associated with March 2018 public offering – Series 2 |  |  | 798,810 |  |  |  | 798,810 |
Warrants to purchase common stock associated with December 2020 public offering - Series 2 |  |  | 6,800,000 |  |  |  | 6,800,000 |
Prefunded warrants to purchase common stock associated with December 2020 public offering |  |  | 3,200,000 |  |  |  | 3,200,000 |
Warrants to purchase common stock associated with April 2022 Public Offering |  |  | 15,000,000 |  |  |  | — |
Prefunded warrants to purchase common stock associated with April 2022 Public Offering |  |  | 11,666,667 |  |  |  | — |
Warrants to purchase common stock associated with Loan Agreement |  |  | 198,819 |  |  |  | 170,410 |
Warrant to purchase common stock associated with Danforth |  |  | 50,000 |  |  |  | 50,000 |
For possible future issuance for the conversion of the March 2019 Notes |  |  | 1,138,200 |  |  |  | 1,138,200 |
For possible future issuance under 2014 Plan (Note 10) |  |  | 62,995 |  |  |  | 295,220 |
For possible future issuance under employee stock purchase plan |  |  | — |  |  |  | 3,893 |
For possible future issuance under 2015 Plan (Note 10) |  |  | 128,250 |  |  |  | 235,000 |
Total common shares reserved for future issuance |  |  | 42,158,758 |  |  |  | 14,367,493 |

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