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v3.23.2

Borrowings - Additional Information (Detail) |  |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
May 13, 2021 USD ($) Tranche | Mar. 07, 2019 USD ($) | Feb. 28, 2023 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2022 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2022 USD ($) | Mar. 30, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Outstanding principal plus all accrued and unpaid interest amount payable to lenders |  |  |  | $ 0 |  | $ 0 |  |  | $ 34,393,000 |
Amortization of debt issuance costs and discount |  |  |  | 1,998,000 | $ 421,000 | 2,256,000 | $ 799,000 |  |  |
Deferred fees, fully paid |  |  | $ 5,800,000 |  |  |  |  |  |  |
Other Liabilities |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Interest rate, deferred fees |  |  |  |  |  |  |  |  | 12.75% | 12.75%
Loan and Security Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Fair value of loan payable |  |  |  |  |  |  |  |  | $ 34,400,000 |
Loan and Security Agreement | Level 3 Inputs | Secured Spread |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, measurement input |  |  |  |  |  |  |  |  | 9.84 |
Loan and Security Agreement | Level 3 Inputs | Risk Free Rate |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, measurement input |  |  |  |  |  |  |  |  | 4.37 |
Loan and Security Agreement | Level 3 Inputs | Secured Yield |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, measurement input |  |  |  |  |  |  |  |  | 14.21 |
Loan Agreement Amendment |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Prepayment fee payable |  |  |  |  |  |  |  | $ 262,500 |  |
Final payment payable under loan agreement |  |  |  |  |  |  |  | 1,382,500 |  |
Loan Agreement Amendment | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront payment | $ 90,000,000.0 |  |  |  |  |  |  |  |  |
Loan Agreement Amendment | Hercules Capital Incorporated And Silicon Valley Bank And Other Lenders |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Outstanding principal plus all accrued and unpaid interest amount payable to lenders |  |  |  |  |  |  |  | $ 35,400,000 |  |
Term Loan | Loan and Security Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Basis spread on variable rate (as a percent) | 9.05% |  |  |  |  |  |  |  |  |
Term Loan | Loan and Security Agreement | Prime Rate |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Basis spread on variable rate (as a percent) | 5.80% |  |  |  |  |  |  |  |  |
Term Loan | Loan and Security Agreement | Hercules Capital Inc. and Silicon Valley Bank |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of available tranches | Tranche | 4 |  |  |  |  |  |  |  |  |
Term Loan | Loan Agreement Amendment |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Face amount | $ 60,000,000.0 |  |  |  |  |  |  |  |  |
Initial Tranche of Term Loan | Loan and Security Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Additional borrowing amount available | 20,000,000.0 |  |  |  |  |  |  |  |  |
Second Tranche of Term Loan | Loan and Security Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Additional borrowing amount available | 10,000,000.0 |  |  |  |  |  |  |  |  |
Third Tranche of Term Loan | Loan and Security Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Additional borrowing amount available | $ 5,000,000.0 |  |  |  |  |  |  |  |  |
Senior Convertible Note Purchase Agreement |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Face amount |  | $ 16,000,000.0 |  |  |  |  |  |  |  |
Notes maturity date |  | Mar. 15, 2025 |  |  |  |  |  |  |  |
Date of issuance and sale of notes |  | Mar. 07, 2019 |  |  |  |  |  |  |  |
Proceeds from debt, net of issuance costs |  | $ 14,700,000 |  |  |  |  |  |  |  |
Payment of debt issuance costs |  | $ 1,300,000 |  |  |  |  |  |  |  |
Senior convertible notes |  |  |  | 11,200,000 |  | 11,200,000 |  |  | $ 11,000,000.0 |
Bifurcated embedded conversion option derivative liability |  |  |  | 400,000 |  | 400,000 |  |  | 42,000,000 |
Derivative, fair value |  |  |  | 7,000,000.0 |  | 7,000,000.0 |  |  |  |
Gain (loss) on fair value adjustment of derivative liability |  |  |  | 42,000,000 | 200,000 | (400,000) | 1,200,000 |  |  |
Amortization of debt issuance costs and discount |  |  |  | 300,000 | $ 200,000 | 300,000 | $ 400,000 |  |  |
Fair value of convertible debt and derivative liability |  |  |  | $ 12,100,000 |  | $ 12,100,000 |  |  | $ 10,800,000 |
Interest rate |  | 6.00% |  |  |  |  |  |  |  |
Payment terms |  |  |  |  |  | The March 2019 Notes bear interest at a rate of 6.0% per annum payable semiannually in arrears on March 15 and September 15 of each year, beginning September 15, 2019. The March 2019 Notes will mature on March 15, 2025, unless earlier converted, redeemed or repurchased. |  |  |  |

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