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Revenue - Additional Information (Detail) - USD ($) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |
--- | --- | --- | --- | --- | ---
Mar. 30, 2023 | Jun. 30, 2023 | Jun. 30, 2023 | Jun. 30, 2022 | Jun. 30, 2023 | Jun. 30, 2022 | Dec. 31, 2022
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Net product revenue |  |  | $ 131,454,000 | $ 1,323,000 | $ 132,584,000 | $ 2,010,000 |
License agreement receivable |  | $ 25,000,000 | 25,000,000 |  | 25,000,000 |  | $ 0
Deferred revenue, current portion |  | 3,229,000 | 3,229,000 |  | 3,229,000 |  | 0
Deferred revenue, long term |  | 1,140,000 | 1,140,000 |  | 1,140,000 |  | $ 0
Product Revenue, Net |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Net product revenue |  |  | 468,000 | 1,323,000 | 1,598,000 | $ 2,010,000 |
GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
License agreement receivable |  | 25,000,000.0 | 25,000,000.0 |  | 25,000,000.0 |  |
License agreement contract asset |  | 19,300,000 | 19,300,000 |  | 19,300,000 |  |
License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Success-based development milestones receivable | $ 45,000,000.0 |  |  |  |  |  |
Revenue recognized |  |  | 500,000 |  |  |  |
Non refundable upfront payment received | 90,000,000 |  |  |  |  |  |
Total transaction price | 136,100,000 |  |  |  |  |  |
Payment of transaction price | 90,000,000.0 |  |  |  |  |  |
License transfer performance obligation revenue | 130,100,000 |  | 130,100,000 |  | 130,100,000 |  |
Research and development activity | 4,800,000 |  |  |  |  |  |
Ongoing clinical and preclinical studies | 1,200,000 |  |  |  |  |  |
License Agreement | GlaxoSmithKline Intellectual Property | License Transfer |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Revenue recognized |  |  |  |  | $ 400,000 |  |
Exclusive License And Collaboration Agreement |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Revenue recognized |  |  | $ 0 | $ 0 |  |  |
Achivement of Threshold Upto 200 Million | License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Sales milestone payable upon achievement of threshold limit | 77,500,000 |  |  |  |  |  |
Achivement of Threshold Upto 300 million to 500 Million | License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Sales milestone payable upon achievement of threshold limit | 65,000,000 |  |  |  |  |  |
Achivement of Threshold Upto 750 million to 1 Billion | License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Sales milestone payable upon achievement of threshold limit | 50,000,000 |  |  |  |  |  |
Successful Completion of Mario Study | License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Success-based development milestones receivable | 10,500,000 |  |  |  |  |  |
Performance-based development milestones receivable |  | $ 25,000,000.0 |  |  |  |  |
Maximum | License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Regulatory milestone payments receivable | 70,000,000 |  |  |  |  |  |
Commercial milestones payments receivable | 115,000,000 |  |  |  |  |  |
Sales milestone payments receivable | 242,500,000 |  |  |  |  |  |
Success-based development milestones receivable | 75,500,000 |  |  |  |  |  |
Maximum | Achivement of Three Interim Milestone of Ongoing Mario Study | License Agreement | GlaxoSmithKline Intellectual Property |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Success-based development milestones receivable | $ 65,000,000 |  |  |  |  |  |
Sales Revenue Net | Customer Concentration Risk | Wholesaler One |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Percentage of gross revenue |  |  |  |  | 46.00% |  |
Sales Revenue Net | Customer Concentration Risk | Wholesaler Two |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Percentage of gross revenue |  |  |  |  | 26.00% |  |
Sales Revenue Net | Customer Concentration Risk | Wholesaler Three |  |  |  |  |  |  |
Disaggregation Of Revenue [Line Items] |  |  |  |  |  |  |
Percentage of gross revenue |  |  |  |  | 25.00% |  |

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