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Debt instrument maximum additional borrowing capacity amount.

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Deferred fees paid.

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Final loan payment payable.

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Number of available tranches

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Prepayment fee payable.

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Upfront payment receivable.

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Amount of amortization expense attributable to debt discount (premium) and debt issuance costs.

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Face (par) amount of debt instrument at time of issuance.

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Effective interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium.

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Contractual interest rate for funds borrowed, under the debt agreement.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Date when the debt instrument is scheduled to be fully repaid, in YYYY-MM-DD format.

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Value of input used to measure debt instrument, including, but not limited to, convertible and non-convertible debt.

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Date the debt instrument was offered for sale, in YYYY-MM-DD format.

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Description of the payment terms of the debt instrument (for example, whether periodic payments include principal and frequency of payments) and discussion about any contingencies associated with the payment.

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Fair value of the assets less the liabilities of a derivative or group of derivatives.

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Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.

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Net Increase or Decrease in the fair value of the embedded derivative or group of embedded derivatives included in earnings in the period.

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Fair value portion of contractual obligation to pay money on demand or on fixed or determinable dates.

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Carrying value as of the balance sheet date of loans payable (with maturities initially due after one year or beyond the operating cycle if longer), excluding current portion.

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The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt.

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The cash inflow from additional borrowings, net of cash paid to third parties in connection with debt origination.

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Borrowings - Additional Information (Detail)			1 Months Ended	3 Months Ended		6 Months Ended
Borrowings - Additional Information (Detail)	May 13, 2021 USD ($) Tranche	Mar. 07, 2019 USD ($)	Feb. 28, 2023 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Mar. 30, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021
Debt Instrument [Line Items]
Outstanding principal plus all accrued and unpaid interest amount payable to lenders				$ 0		$ 0			$ 34,393,000
Amortization of debt issuance costs and discount				1,998,000	$ 421,000	2,256,000	$ 799,000
Deferred fees, fully paid			$ 5,800,000
Other Liabilities
Debt Instrument [Line Items]
Interest rate, deferred fees									12.75%	12.75%
Loan and Security Agreement
Debt Instrument [Line Items]
Fair value of loan payable									$ 34,400,000
Loan and Security Agreement \| Level 3 Inputs \| Secured Spread
Debt Instrument [Line Items]
Debt instrument, measurement input									9.84
Loan and Security Agreement \| Level 3 Inputs \| Risk Free Rate
Debt Instrument [Line Items]
Debt instrument, measurement input									4.37
Loan and Security Agreement \| Level 3 Inputs \| Secured Yield
Debt Instrument [Line Items]
Debt instrument, measurement input									14.21
Loan Agreement Amendment
Debt Instrument [Line Items]
Prepayment fee payable								$ 262,500
Final payment payable under loan agreement								1,382,500
Loan Agreement Amendment \| GlaxoSmithKline Intellectual Property
Debt Instrument [Line Items]
Upfront payment	$ 90,000,000.0
Loan Agreement Amendment \| Hercules Capital Incorporated And Silicon Valley Bank And Other Lenders
Debt Instrument [Line Items]
Outstanding principal plus all accrued and unpaid interest amount payable to lenders								$ 35,400,000
Term Loan \| Loan and Security Agreement
Debt Instrument [Line Items]
Basis spread on variable rate (as a percent)	9.05%
Term Loan \| Loan and Security Agreement \| Prime Rate
Debt Instrument [Line Items]
Basis spread on variable rate (as a percent)	5.80%
Term Loan \| Loan and Security Agreement \| Hercules Capital Inc. and Silicon Valley Bank
Debt Instrument [Line Items]
Number of available tranches \| Tranche	4
Term Loan \| Loan Agreement Amendment
Debt Instrument [Line Items]
Face amount	$ 60,000,000.0
Initial Tranche of Term Loan \| Loan and Security Agreement
Debt Instrument [Line Items]
Additional borrowing amount available	20,000,000.0
Second Tranche of Term Loan \| Loan and Security Agreement
Debt Instrument [Line Items]
Additional borrowing amount available	10,000,000.0
Third Tranche of Term Loan \| Loan and Security Agreement
Debt Instrument [Line Items]
Additional borrowing amount available	$ 5,000,000.0
Senior Convertible Note Purchase Agreement
Debt Instrument [Line Items]
Face amount		$ 16,000,000.0
Notes maturity date		Mar. 15, 2025
Date of issuance and sale of notes		Mar. 07, 2019
Proceeds from debt, net of issuance costs		$ 14,700,000
Payment of debt issuance costs		$ 1,300,000
Senior convertible notes				11,200,000		11,200,000			$ 11,000,000.0
Bifurcated embedded conversion option derivative liability				400,000		400,000			42,000,000
Derivative, fair value				7,000,000.0		7,000,000.0
Gain (loss) on fair value adjustment of derivative liability				42,000,000	200,000	(400,000)	1,200,000
Amortization of debt issuance costs and discount				300,000	$ 200,000	300,000	$ 400,000
Fair value of convertible debt and derivative liability				$ 12,100,000		$ 12,100,000			$ 10,800,000
Interest rate		6.00%
Payment terms						The March 2019 Notes bear interest at a rate of 6.0% per annum payable semiannually in arrears on March 15 and September 15 of each year, beginning September 15, 2019. The March 2019 Notes will mature on March 15, 2025, unless earlier converted, redeemed or repurchased.