XML 56 R45.htm IDEA: XBRL DOCUMENT

Stockholders' Equity - Schedule of Reserved Shares of Common Stock for Future Issuance (Detail) - shares	Jun. 30, 2023	Dec. 31, 2022
Class of Stock [Line Items]
Common shares reserved for future issuance	39,145,393	42,489,050
Stock options
Class of Stock [Line Items]
Common shares reserved for future issuance	1,970,536	1,740,308
Restricted Stock Units
Class of Stock [Line Items]
Common shares reserved for future issuance	2,194,251	633,270
Warrant \| March 2018 Public Offering
Class of Stock [Line Items]
Common shares reserved for future issuance	0	798,810
Warrant \| December 2020 Public Offering Series 2
Class of Stock [Line Items]
Common shares reserved for future issuance	6,800,000	6,800,000
Warrant \| Prefunded Warrants to Purchase Common Stock Associated with December 2020 Public Offering
Class of Stock [Line Items]
Common shares reserved for future issuance	3,200,000	3,200,000
Warrant \| Warrants to Purchase Common Stock Associated With April 2022 Public Offering
Class of Stock [Line Items]
Common shares reserved for future issuance	15,000,000	15,000,000
Warrant \| April 2022 Public Offering
Class of Stock [Line Items]
Common shares reserved for future issuance	7,516,267	11,666,667
Warrant \| Warrant to purchase common stock associated with Danforth
Class of Stock [Line Items]
Common shares reserved for future issuance	50,000	50,000
Warrant \| Warrants to purchase common stock associated with Loan Agreement
Class of Stock [Line Items]
Common shares reserved for future issuance	198,811	198,811
March 2019 Notes
Class of Stock [Line Items]
Common shares reserved for future issuance	1,138,200	1,138,200
2014 Employee Stock Purchase Plan
Class of Stock [Line Items]
Common shares reserved for future issuance	279	0
2014 Plan
Class of Stock [Line Items]
Common shares reserved for future issuance	504,074	712,020
2015 Plan
Class of Stock [Line Items]
Common shares reserved for future issuance	572,975	550,964