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Revenue - Additional Information (Detail) - USD ($)		1 Months Ended	3 Months Ended		6 Months Ended
	Mar. 30, 2023	Jun. 30, 2023	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Disaggregation Of Revenue [Line Items]
Net product revenue			$ 131,454,000	$ 1,323,000	$ 132,584,000	$ 2,010,000
License agreement receivable		$ 25,000,000	25,000,000		25,000,000		$ 0
Deferred revenue, current portion		3,229,000	3,229,000		3,229,000		0
Deferred revenue, long term		1,140,000	1,140,000		1,140,000		$ 0
Product Revenue, Net
Disaggregation Of Revenue [Line Items]
Net product revenue			468,000	1,323,000	1,598,000	$ 2,010,000
GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
License agreement receivable		25,000,000.0	25,000,000.0		25,000,000.0
License agreement contract asset		19,300,000	19,300,000		19,300,000
License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Success-based development milestones receivable	$ 45,000,000.0
Revenue recognized			500,000
Non refundable upfront payment received	90,000,000
Total transaction price	136,100,000
Payment of transaction price	90,000,000.0
License transfer performance obligation revenue	130,100,000		130,100,000		130,100,000
Research and development activity	4,800,000
Ongoing clinical and preclinical studies	1,200,000
License Agreement | GlaxoSmithKline Intellectual Property | License Transfer
Disaggregation Of Revenue [Line Items]
Revenue recognized					$ 400,000
Exclusive License And Collaboration Agreement
Disaggregation Of Revenue [Line Items]
Revenue recognized			$ 0	$ 0
Achivement of Threshold Upto 200 Million | License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Sales milestone payable upon achievement of threshold limit	77,500,000
Achivement of Threshold Upto 300 million to 500 Million | License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Sales milestone payable upon achievement of threshold limit	65,000,000
Achivement of Threshold Upto 750 million to 1 Billion | License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Sales milestone payable upon achievement of threshold limit	50,000,000
Successful Completion of Mario Study | License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Success-based development milestones receivable	10,500,000
Performance-based development milestones receivable		$ 25,000,000.0
Maximum | License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Regulatory milestone payments receivable	70,000,000
Commercial milestones payments receivable	115,000,000
Sales milestone payments receivable	242,500,000
Success-based development milestones receivable	75,500,000
Maximum | Achivement of Three Interim Milestone of Ongoing Mario Study | License Agreement | GlaxoSmithKline Intellectual Property
Disaggregation Of Revenue [Line Items]
Success-based development milestones receivable	$ 65,000,000
Sales Revenue Net | Customer Concentration Risk | Wholesaler One
Disaggregation Of Revenue [Line Items]
Percentage of gross revenue					46.00%
Sales Revenue Net | Customer Concentration Risk | Wholesaler Two
Disaggregation Of Revenue [Line Items]
Percentage of gross revenue					26.00%
Sales Revenue Net | Customer Concentration Risk | Wholesaler Three
Disaggregation Of Revenue [Line Items]
Percentage of gross revenue					25.00%

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