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Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Shares (Detail) - shares
3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 26,503,613 27,332,890
Outstanding stock options    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 2,716,602 1,931,389
Outstanding restricted stock units    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 600,000 2,214,490
December 2020 Public Offering Series 2 | Warrant    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 6,800,000 6,800,000
April 2022 Public Offering | Warrant    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 15,000,000 15,000,000
Warrants to purchase common stock associated with Loan Agreement | Warrant    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 198,811 198,811
Common stock associated with March 2019 Notes    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 1,138,200 1,138,200
Warrants to purchase common stock associated with Danforth | Warrant    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Anti-dilutive securities (in shares) 50,000 50,000