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v3.25.0.1

Borrowings - Additional Information (Detail) |  |  | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
May 13, 2021 USD ($) | Mar. 07, 2019 USD ($) $ / shares | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Mar. 31, 2023 USD ($) | Mar. 30, 2023 USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |
Amortization for remaining debt issuance costs and discount |  |  |  | $ 1,900,000 |  |
Amortization of debt issuance costs and discount |  |  | $ 1,726,000 | 2,994,000 |  |
Loan Agreement Amendment |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Prepayment fee payable |  |  |  |  |  | $ 262,500
Final payment payable under loan agreement |  |  |  |  |  | 1,382,500
Loan Agreement Amendment | GlaxoSmithKline Intellectual Property |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Upfront payment | $ 90,000,000 |  |  |  |  |
Loan Agreement Amendment | Hercules Capital Inc. and Silicon Valley Bank |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Prepayment fee payable |  |  |  |  | $ 35,000,000 |
Loan Agreement Amendment | Hercules Capital Incorporated And Silicon Valley Bank And Other Lenders |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Loan payable (Note 8) |  |  |  |  |  | $ 35,400,000
Senior Convertible Note Purchase Agreement |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Face amount |  | $ 16,000,000 |  |  |  |
Notes maturity date |  |  | Mar. 15, 2025 |  |  |
Date of issuance and sale of notes |  | Mar. 07, 2019 |  |  |  |
Proceeds from debt, net of issuance costs |  | $ 14,700,000 |  |  |  |
Payment of debt issuance costs |  | $ 1,300,000 |  |  |  |
Purchase price as percentage of principal amount |  | 100.00% |  |  |  |
Interest rate |  | 6.00% |  |  |  |
Payment terms |  |  | The March 2019 Notes bear interest at a rate of 6.0% per annum payable semiannually in arrears on March 15 and September 15 of each year, beginning September 15, 2019. The March 2019 Notes will mature on March 15, 2025, unless earlier converted, redeemed or repurchased. The March 2019 Notes constitute general, senior unsecured obligations of the Company. |  |  |
Senior convertible notes |  |  | $ 13,700,000 | 12,000,000 |  |
Bifurcated embedded conversion option derivative liability |  |  | 0 | 200,000 |  |
Derivative, fair value |  |  | 7,000,000 |  |  |
Gain (loss) on fair value adjustment of derivative liability |  |  | 200,000 | 200,000 |  |
Amortization of debt issuance costs and discount |  |  | $ 1,700,000 | $ 1,000,000 |  |
Conversion terms |  |  | holder of the March 2019 Notes may convert their March 2019 Notes at their option at any time prior to the close of business on the business day immediately preceding March 15, 2025 into shares of the Company’s common stock. |  |  |
Conversion rate, number of shares to be issued per $1000 of principal (in shares) |  | 73.9096 |  |  |  |
Principal amount of notes used as the denominator for conversion into notes |  | $ 1,000 |  |  |  |
Initial conversion price of notes | $ / shares |  | $ 13.53 |  |  |  |
Conversion rate, number of shares to be issued per $1000 of principal (in shares) after adjustment to certain events |  | 81 |  |  |  |
Principal amount of notes used as the denominator for conversion into notes after adjustment of certain events |  | $ 1,000 |  |  |  |

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