Aggregate initial number of common shares reserved for future issuance.

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Number of shares unvailable for grant.

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Fair value of share-based awards for which the grantee gained the right by satisfying service and performance requirements, to receive or retain shares or units, other instruments, or cash.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Stock-based Compensation - Additional Information (Details) - USD ($)		12 Months Ended
	Jan. 01, 2024	Dec. 31, 2024	Dec. 31, 2023	Mar. 28, 2024	Mar. 20, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares reserved for future issuance		7,107,023
Common stock, shares issued		13,481,917	5,754,505
Stock issued on exercise of stock options, Shares		12,852
Number of options, forfeited		228,475
Acceleration of stock awards		$ 10,500,000
Number of options, granted		1,326,500
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Aggregate grant date fair value of RSUs vested		$ 0
Research and Development
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense		840,000	$ 2,449,000
General and Administrative
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense		1,473,000	9,590,000
Graybug
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Acceleration of stock awards		$ 10,500,000	10,500,000
Graybug \| Research and Development
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense			1,900,000
Graybug \| General and Administrative
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense			$ 8,600,000
2020 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares unavailable for grant (shares)		223,743
2023 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares reserved for future issuance		807,414		1,500,000	1,000,000
Percentage of aggregate number of shares of common stock outstanding on last day of preceding year added to plan		5.00%
Number of options, forfeited		228,475
Increase in number of shares reserved for issuance	287,725
Shares available for grant (shares)		820,266
2023 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares reserved for future issuance		122,545
Common stock shares reserved for future issuance, initial		65,000
Weighted average fair value options, granted		$ 4.14	$ 2.34
Total fair value of shares vested		$ 5,000,000	$ 11,900,000
Common stock, shares issued		195,000
Stock issued on exercise of stock options, Shares		12,852
Percentage of aggregate number of shares of common stock outstanding on last day of preceding year added to plan		1.00%
Increase in number of shares reserved for issuance		57,545
Stock Issued		0
Total unrecognized stock-based compensation expenses related to outstanding unvested stock awards		$ 4,700,000
Total unrecognized stock-based compensation expenses related to outstanding unvested stock awards weighted-average term of recognition		2 years 9 months 18 days
Number of options, granted		1,326,500