<SEC-DOCUMENT>0001193125-25-269496.txt : 20251106
<SEC-HEADER>0001193125-25-269496.hdr.sgml : 20251106
<ACCEPTANCE-DATETIME>20251106160628
ACCESSION NUMBER:		0001193125-25-269496
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20251106
DATE AS OF CHANGE:		20251106

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CalciMedica, Inc.
		CENTRAL INDEX KEY:			0001534133
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				452120079
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-273949
		FILM NUMBER:		251458216

	BUSINESS ADDRESS:	
		STREET 1:		505 COAST BOULEVARD SOUTH
		STREET 2:		SUITE 307
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037
		BUSINESS PHONE:		858-952-5500

	MAIL ADDRESS:	
		STREET 1:		505 COAST BOULEVARD SOUTH
		STREET 2:		SUITE 307
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CalciMedica, Inc. /DE/
		DATE OF NAME CHANGE:	20230322

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GRAYBUG VISION, INC.
		DATE OF NAME CHANGE:	20170717

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GRAYBUG, Inc.
		DATE OF NAME CHANGE:	20150303
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>d65924d424b5.htm
<DESCRIPTION>424B5
<TEXT>
<HTML><HEAD>
<TITLE>424B5</TITLE>
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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Filed Pursuant to Rule 424(b)(5) </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Registration <FONT STYLE="white-space:nowrap">No.&nbsp;333-273949</FONT></B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>PROSPECTUS SUPPLEMENT </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">(To Prospectus Supplement dated <A HREF="http://www.sec.gov/Archives/edgar/data/1534133/000119312524283094/d824183d424b5.htm">December&nbsp;20,
 2024 </A> </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">To Prospectus dated <A HREF="http://www.sec.gov/Archives/edgar/data/1534133/000119312523210902/d516230ds3.htm">August&nbsp;18, 2023</A>) </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="center">


<IMG SRC="g65924g1105143249903.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:Times New Roman" ALIGN="center"><B>Up to $9,700,000 of Shares of </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:Times New Roman" ALIGN="center"><B>Common Stock </B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center><DIV STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</DIV></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">This prospectus supplement amends and supplements the information in our prospectus dated August&nbsp;18, 2023, as supplemented by the
prospectus supplement dated December&nbsp;20, 2024 (the &#8220;Prior Prospectus Supplement&#8221;, and, together with the accompanying prospectus, the &#8220;Prior Prospectus&#8221;), filed as part of our registration statement on Form <FONT
STYLE="white-space:nowrap">S-3</FONT> (<A HREF="http://www.sec.gov/Archives/edgar/data/1534133/000119312523210902/d516230ds3.htm">File <FONT STYLE="white-space:nowrap">No.&nbsp;333-273949</FONT></A>). This prospectus supplement should be read in
conjunction with the Prior Prospectus, and is qualified by reference thereto, except to the extent that the information herein amends or supersedes the information contained in the Prior Prospectus. This prospectus supplement is not complete
without, and may only be delivered or utilized in connection with, the Prior Prospectus, and any future amendments or supplements thereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">We filed the Prior Prospectus to register the offer and sale of our common stock, par value $0.0001 per share, from time to time pursuant to
the terms of that certain at the market offering agreement (the &#8220;Offering Agreement&#8221;), between H.C. Wainwright&nbsp;&amp; Co., LLC (&#8220;Wainwright&#8221;), acting as sales agent, and us. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">We are filing this prospectus supplement to amend the Prior Prospectus to update the amount of shares we are eligible to sell under General
Instruction I.B.6 on Form <FONT STYLE="white-space:nowrap">S-3.</FONT> As a result of these limitations and the current public float of our common stock, and in accordance with the terms of the Offering Agreement, we may offer and sell shares of our
common stock having an aggregate offering price of up to $9,700,000 from time to time through Wainwright, as further described below. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
of the date of this prospectus supplement, the aggregate market value of our common stock held by <FONT STYLE="white-space:nowrap">non-affiliates</FONT> of our public float was approximately $36.3&nbsp;million based on a total number of 14,399,531
shares of common stock outstanding, of which 10,146,506 shares of common stock were held by <FONT STYLE="white-space:nowrap">non-affiliates,</FONT> at a price of $3.58 per share, the closing sales price of our common stock on September&nbsp;9, 2025,
which is the highest closing price of our common stock on the Nasdaq Capital Market within the prior 60 days. We have sold $2.3&nbsp;million of securities pursuant to General Instruction I.B.6 of Form <FONT STYLE="white-space:nowrap">S-3</FONT>
during the prior <FONT STYLE="white-space:nowrap">12-calendar</FONT> month period that ends on and includes the date of this prospectus supplement (excluding this offering). Accordingly, based on the foregoing, we are currently eligible under
General Instruction I.B.6 of Form <FONT STYLE="white-space:nowrap">S-3</FONT> to offer and sell shares of our common stock having an aggregate offering price of up to $9,700,000. Pursuant to General Instruction I.B.6 of Form <FONT
STYLE="white-space:nowrap">S-3,</FONT> in no event will we sell securities in a public primary offering with a value exceeding <FONT STYLE="white-space:nowrap">one-third</FONT> of our public float in any
<FONT STYLE="white-space:nowrap">12-month</FONT> period so long as our public float remains below $75.0&nbsp;million. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Our common stock is
listed on the Nasdaq Capital Market under the trading symbol &#8220;CALC.&#8221; On November&nbsp;5, 2025, the last reported sale price of our common stock was $3.03 per share. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><B>Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or
determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense. </B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center><DIV STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</DIV></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B>H.C. Wainwright&nbsp;&amp; Co. </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>The date of this prospectus supplement is November&nbsp;6, 2025. </B></P>
</DIV></Center>

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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
