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Research and development expenses | 12 Months Ended
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Dec. 31, 2022
Research and development expenses |
Research and development expenses | 5. Research and development expenses Research and development expenses include the following categories: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | For the Year Ended December 31,
(in thousands) |  | 2022 |  | 2021 |  | 2020
Pre-clinical and clinical trial expenses | ​ | $ | 28,178 | ​ | $ | 14,188 | ​ | $ | 11,325
Personnel-related expenses | ​ | ​ | 6,150 | ​ | ​ | 4,955 | ​ | ​ | 2,276
Research and development activities expenses | ​ | ​ | 2,241 | ​ | ​ | 1,843 | ​ | ​ | 1,022
Share-based compensation expense | ​ | ​ | 1,975 | ​ | ​ | 788 | ​ | ​ | 232
Facilities and other research and development expenses | ​ | ​ | 1,546 | ​ | ​ | 814 | ​ | ​ | 643
VUmc and other license expenses | ​ | ​ | 15 | ​ | ​ | 14,357 | ​ | ​ | 203
​ | ​ | $ | 40,105 | ​ | $ | 36,945 | ​ | $ | 15,701
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Refer to Note 22 for additional information about VUmc license expenses. Government grants, which are a reduction of payroll taxes in the Netherlands, amounted to $1.6 million in 2022, $1.7 million in 2021, and $1.0 million in 2020. These amounts are an offset to wages and salaries that are part of our research and development expenses in the income statement. The increase in the respective periods was primarily due to increased research activities in the Netherlands.

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