For the Year Ended December 31,

(in thousands)

2022

2021

2020

Pre-clinical and clinical trial expenses

$

28,178

$

14,188

$

11,325

Personnel-related expenses

6,150

4,955

2,276

Research and development activities expenses

2,241

1,843

1,022

Share-based compensation expense

1,975

788

232

Facilities and other research and development expenses

1,546

814

643

VUmc and other license expenses

15

14,357

203

$

40,105

$

36,945

$

15,701