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Consolidated statements of cash flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities:      
Loss before income tax $ (31,658) $ (42,198) $ (15,884)
Adjusted for:      
Depreciation and amortization of non-current assets 504 331 213
Foreign currency exchange (gain) loss, net (2,923) (2,040) 869
Amortization of right-of-use assets 277 227 251
Share-based compensation expense 4,113 3,907 557
Income tax expense (249) (157) (43)
Amortization of premium on investments (134) 446  
Changes in working capital:      
Receivables and other (2,891) 777 (1,072)
VAT receivable 416 (35) (186)
Prepaid expenses and other assets (1,857) (2,859) (795)
Trade accounts payable and other 1,413 1,618 323
Deferred offering & financing costs   1,623 (323)
Deferred revenue 33,510 (4,649) 6,176
License liabilities (2,828) 13,713  
Other liabilities 6,350 649 607
Net cash provided by (used in) operating activities 4,043 (28,647) (9,307)
Cash flows from investing activities:      
Purchases of property and equipment (587) (764) (502)
Purchases of investments (70,877) (45,291)  
Maturities of investments 80,810 2,510  
Net cash provided by (used in) investing activities 9,346 (43,545) (502)
Cash flows from financing activities:      
Proceeds from option exercises 15    
Proceeds from common shares from initial public offering, net   94,189  
Proceeds from Series C financing, net   61,798 22,025
Payment of Series A preferred and common shares repurchased   (5,167) (4,849)
Proceeds from borrowings 611 680 2,033
Payment of principal portion of lease liabilities (343) (340) (240)
Net cash provided by financing activities 283 151,160 18,969
Net increase in cash and cash equivalents 13,672 78,968 9,160
Cash and cash equivalents at beginning of year 90,869 15,818 7,338
Effects of exchange rate changes (4,208) (3,917) (680)
Cash and cash equivalents at end of year 100,333 90,869 15,818
Supplemental schedule of noncash operating and financing activities:      
Issuance of common shares to VUmc in lieu of payment for license liabilities $ 2,201 $ 3,655  
Deferred offering costs in accounts payable and accrued expenses     $ 489