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Equity - Stock options - Compensation cost (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Share-based compensation |  |
Compensation cost, Effect on loss | $ 568,000 | $ 224,000
Effect on net loss per share (in dollars per share) | $ 0.02 | $ 0.01
Research and development |  |
Share-based compensation |  |
Compensation cost, Effect on loss | $ 174,000 | $ 145,000
General and administrative |  |
Share-based compensation |  |
Compensation cost, Effect on loss | $ 394,000 | $ 79,000

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