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Research and Collaboration Agreements (Details) € in Thousands |  | 3 Months Ended |  |
--- | --- | --- | --- | ---
Jun. 30, 2017 USD ($) | Jun. 30, 2017 EUR (€) | Mar. 31, 2019 USD ($) collaboration_project | Mar. 31, 2018 USD ($) | Dec. 31, 2018 USD ($) | Jun. 30, 2017 EUR (€)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Duration of agreement | 2 years | 2 years |  |  |  |
Payment for research and development agreement | $ 1,100,000 | € 1,000 |  |  |  |
Prepaid research and development | $ |  |  | $ 200,000 |  | $ 300,000 |
Research and development - related party | $ |  |  | 389,473 | $ 392,549 |  |
RSA |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Payment for research and development agreement | € |  | € 1,000 |  |  |  |
Payment for additional development and commercialization | € |  |  |  |  |  | € 1,500
RSA | Minimum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue sharing, percentage | 50.00% | 50.00% |  |  |  |
RSA | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue sharing, percentage | 75.00% | 75.00% |  |  |  |
RSA | BDI Holdings |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Equity interest acquired | 16.10% | 16.10% |  |  |  |
RSA | VLPbio |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Equity interest acquired | 3.30% | 3.30% |  |  |  |
RSA | BDI |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Duration of agreement | 2 years | 2 years |  |  |  |
Obligation for payment for research and development, minimum | € |  |  |  |  |  | 936
Obligation for payment for research and development, maximum | € |  |  |  |  |  | € 8,000
RSA | BDI | Minimum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue sharing, percentage | 50.00% | 50.00% |  |  |  |
RSA | BDI | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue sharing, percentage | 75.00% | 75.00% |  |  |  |
SFA |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Duration of agreement | 2 years | 2 years |  |  |  |
Obligation for payment for research and development, minimum | $ | $ 1,000,000 |  |  |  |  |
Outstanding commitment | $ | $ 1,000,000 |  | $ 0 |  |  |
Number of collaboration project, completed | collaboration_project |  |  | 4 |  |  |
Number of collaboration project, in progress | collaboration_project |  |  | 1 |  |  |

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