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Organization and Summary of Significant Accounting Policies - Research and Development Costs (Details) - USD ($) | 3 Months Ended
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Mar. 31, 2019 | Mar. 31, 2018
Accounting Policies [Abstract] |  |
Outside contracted services | $ 585,487 | $ 469,557
Contracted services - related party | 389,473 | 392,549
Personnel related costs | 94,762 | 94,991
Facilities, overhead and other | 12,121 | 12,336
Research and development expense, related party, net | $ 1,081,843 | $ 969,433

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