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v3.19.1

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Cash flows from operating activities |  |
Net loss | $ (2,175,258) | $ (2,043,292)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 309,563 | 269,596
Amortization of held-to-maturity securities, net | 32,201 | 284,730
Foreign currency exchange loss, net | 5,148 | 4,840
Changes in operating assets and liabilities: |  |
Interest receivable | 3,981 | 21,044
Accounts receivable | (106,781) | 171,841
Income tax receivable | 6,249 | 0
Prepaid research and development | 83,112 | 360,711
Prepaid expenses and other current assets | 5,049 | 55,209
Accounts payable | 641,799 | (57,039)
Accrued expenses | (96,606) | 207,572
Deferred research and development obligation | (117,978) | 166,024
Income taxes payable | 0 | (102,000)
Net cash used in operating activities | (1,409,521) | (660,764)
Cash flows from investing activities |  |
Purchases of held-to-maturity investment securities | (13,190,855) | (17,761,999)
Proceeds from maturities of investment securities | 16,197,000 | 17,639,000
Net cash provided by (used in) investing activities | 3,006,145 | (122,999)
Cash flows from financing activities |  |
Repurchases of common stock | 0 | (374,820)
Net cash used in financing activities | 0 | (374,820)
Effect of exchange rate changes on cash | (7,177) | 3,547
Net increase (decrease) in cash, cash equivalents and restricted cash | 1,589,447 | (1,155,036)
Cash, cash equivalents and restricted cash at beginning of period | 2,386,314 | 5,786,348
Cash, cash equivalents and restricted cash at end of period | 3,975,761 | 4,631,312
Supplemental cash flow information |  |
Cash refund received from income tax | $ 6,249 | $ 102,000

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