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Research Collaboration and Sub-licensing Agreements (Details) € in Thousands |  |  |  | 3 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
May 07, 2019 antibody_and_vaccine protein | May 05, 2019 | Jun. 30, 2017 USD ($) | Jun. 30, 2017 EUR (€) | Jun. 30, 2019 USD ($) collaboration_project | Jun. 30, 2018 USD ($) | Jun. 30, 2019 USD ($) collaboration_project | Jun. 30, 2018 USD ($) | Apr. 26, 2019 | Dec. 31, 2018 USD ($) | Jun. 30, 2017 EUR (€)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Duration of agreement |  |  | 2 years | 2 years |  |  |  |  |  |  |
Payment for research and development agreement |  |  | $ 1,100,000 | € 1,000 |  |  |  |  |  |  |
Prepaid research and development | $ |  |  |  |  | $ 100,000 |  | $ 100,000 |  |  | $ 300,000 |
Research and development - related party | $ |  |  |  |  | $ 336,310 | $ 340,849 | $ 725,783 | $ 733,398 |  |  |
Collaborative Arrangement | Serum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of antibodies and vaccines for development and commercialization | antibody_and_vaccine | 12 |  |  |  |  |  |  |  |  |  |
Option to obtain exclusive commercial sub-license for number of proteins | protein | 12 |  |  |  |  |  |  |  |  |  |
Research funding, milestone payments and royalties, period | 15 years |  |  |  |  |  |  |  |  |  |
Novovet |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Equity percentage |  |  |  |  |  |  |  |  | 20.00% |  |
Alphazyme |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Equity percentage |  | 7.50% |  |  |  |  |  |  |  |  |
Ownership interest consideration receivable upon extension of exclusivity period |  | 2.50% |  |  |  |  |  |  |  |  |
Alphazyme | Collaborative Arrangement |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Exclusivity period |  | 18 months |  |  |  |  |  |  |  |  |
Option to extend exclusivity period |  | 12 months |  |  |  |  |  |  |  |  |
RSA |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payment for research and development agreement | € |  |  |  | € 1,000 |  |  |  |  |  |  |
Payment for additional development and commercialization | € |  |  |  |  |  |  |  |  |  |  | € 1,500
RSA | Minimum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue sharing, percentage |  |  | 50.00% | 50.00% |  |  |  |  |  |  |
RSA | Maximum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue sharing, percentage |  |  | 75.00% | 75.00% |  |  |  |  |  |  |
RSA | BDI Holdings |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Equity interest acquired |  |  | 16.10% | 16.10% |  |  |  |  |  |  |
RSA | VLPbio |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Equity interest acquired |  |  | 3.30% | 3.30% |  |  |  |  |  |  |
RSA | BDI |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Duration of agreement |  |  | 2 years | 2 years |  |  |  |  |  |  |
Obligation for payment for research and development, minimum | € |  |  |  |  |  |  |  |  |  |  | 936
Obligation for payment for research and development, maximum | € |  |  |  |  |  |  |  |  |  |  | € 8,000
RSA | BDI | Minimum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue sharing, percentage |  |  | 50.00% | 50.00% |  |  |  |  |  |  |
RSA | BDI | Maximum |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue sharing, percentage |  |  | 75.00% | 75.00% |  |  |  |  |  |  |
SFA |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Duration of agreement |  |  | 2 years | 2 years |  |  |  |  |  |  |
Obligation for payment for research and development, minimum | $ |  |  | $ 1,000,000 |  |  |  |  |  |  |  |
Outstanding commitment | $ |  |  | $ 1,000,000 |  |  |  |  |  |  |  |
Number of collaboration project, completed | collaboration_project |  |  |  |  | 4 |  | 4 |  |  |  |
Number of collaboration project, in progress | collaboration_project |  |  |  |  | 3 |  | 3 |  |  |  |

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