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Note 1 - Organization and Summary of Significant Accounting Policies - Accrued Expenses (Details) - USD ($)
Dec. 31, 2020
Dec. 31, 2019
Employee wages and benefits $ 447,881 $ 474,388
Research and development expenses 28,508 69,795
Other 13,367 21,820
Accrued Liabilities, Current, Total $ 489,756 $ 566,003