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Note 1 - Organization and Summary of Significant Accounting Policies - Research and Development Costs (Details) - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Outside contracted services $ 3,302,034 $ 2,578,507
Contracted services - related party 0 868,720
Personnel related costs 531,405 423,898
Facilities, overhead and other 34,682 85,192
Research And Development Expense, Including Related Party $ 3,868,121 $ 3,956,317