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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($) | 3 Months Ended
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Mar. 31, 2021 | Mar. 31, 2020
Stock-based compensation | $ 421,071 | $ 426,939
General and Administrative Expense [Member] |  |
Stock-based compensation | 377,052 | 380,251
Research and Development Expense [Member] |  |
Stock-based compensation | $ 44,019 | $ 46,688

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