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Note 5 - Share-based Compensation (Tables)
3 Months Ended
Mar. 31, 2021
Notes Tables  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Risk-Free interest rate

  0.13%-0.55% 

Expected dividend yield

  —% 

Expected stock price volatility

  54.52%-56.07% 

Expected life of options (in years)

  2.00-6.25 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
          

Weighted-Average

     
      

Weighted-Average

  

Remaining Contractual

  

Aggregate Intrinsic

 
  

Shares

  

Exercise Price

  

Term (Years)

  

Value

 

Outstanding at December 31, 2020

  4,638,390  $2.44   5.64  $13,701,610 

Granted (1)

  745,825   5.25         

Exercised (2)

  (60,000)  1.93         

Expired

              

Canceled

              

Outstanding at March 31, 2021

  5,324,215  $2.84   6.03  $14,209,431 
                 

Exercisable at March 31, 2021

  4,016,141  $2.28   5.09  $12,927,908 
Share-based Payment Arrangement, Activity [Table Text Block]
  

Three Months Ended March 31,

 
  

2021

  

2020

 

General and administrative

 $377,052  $380,251 

Research and development

  44,019   46,688 

Total

 $421,071  $426,939