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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($)	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Stock-based compensation	$ 421,071	$ 426,939
General and Administrative Expense [Member]
Stock-based compensation	377,052	380,251
Research and Development Expense [Member]
Stock-based compensation	$ 44,019	$ 46,688

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
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-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5047-113901

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-URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

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