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Note 3 - Research and Collaboration Agreements, Sublicense Agreements, and Investments in Privately-held Companies (Details Textual)					3 Months Ended		6 Months Ended
	Jul. 26, 2021 EUR (€)	Jun. 24, 2020	Jun. 30, 2017 USD ($)	Jun. 30, 2017 EUR (€)	Jun. 30, 2021 USD ($)	Jun. 30, 2020 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2020 USD ($)	Jul. 08, 2021 shares	Dec. 31, 2020 USD ($)	Dec. 01, 2020	Apr. 26, 2019	Jun. 30, 2017 EUR (€)
Cost of Goods and Services Sold, Total					$ 829,504	$ 624,240	$ 1,220,266	$ 902,422
Research and Development Expense, Total					2,209,242	$ 1,116,163	4,017,340	$ 1,871,616
Collaborative Arrangement, Payment for Research and Development Agreement			$ 1,100,000
Novovet [Member]
Equity Method Investment, Ownership Percentage												20.00%
Alphazyme [Member]
Sale of Stock, Percentage of Ownership after Transaction		2.50%
Equity Securities without Readily Determinable Fair Value, Amount										$ 284,709
BDI Holdings [Member]
Cost of Goods and Services Sold, Total					33,000		48,000
Research and Development Expense, Total					$ 33,000		$ 33,000
Subsequent Event [Member] \| BDI Holdings and VLPBio [Member] \| Discontinued Operations, Disposed of by Sale [Member]
Proceeds from Divestiture of Businesses and Interests in Affiliates, Total \| €	€ 1,300,000
Research Services Agreement [Member]
Collaborative Arrangement, Payment for Additional Development and Commercialization \| €													€ 1,500,000
Service Framework Agreement [Member]
Collaborative Arrangement, Minimum Obligation For Research and Development			$ 1,000,000.0
Collaborative Arrangement, Duration Of Agreement (Year)			2 years	2 years
Collaborative Arrangement, Outstanding Commitment			$ 1,000,000.0
BDI Holdings [Member] \| Subsequent Event [Member]
Ownership Percentage	16.10%
VLPBio Member \| Subsequent Event [Member]
Ownership Percentage	3.30%
Alphazyme [Member]
Ownership Percentage											1.99%
ID Biologics Inc [Member] \| Subsequent Event [Member]
Investment Owned, Balance, Shares (in shares) \| shares									129,661
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners									0.37%
Research Services Agreement [Member]
Collaborative Arrangement, Payment for Research and Development Agreement \| €				€ 1,000,000.0
Research Services Agreement [Member] \| BDI Holdings [Member]
Collaborative Arrangement, Equity Interest Acquired			16.10%	16.10%
Collaborative Arrangement, Minimum Obligation For Research and Development \| €													936,000
Collaborative Arrangement, Duration Of Agreement (Year)			2 years	2 years
Collaborative Arrangement, Maximum Obligation For Research and Development \| €													8,000,000.0
Research Services Agreement [Member] \| BDI Holdings [Member] \| Minimum [Member]
Collaborative Arrangement, Minimum Obligation For Research and Development \| €													€ 1,000,000
Collaborative Arrangement, Revenue Sharing, Percentage			50.00%	50.00%
Research Services Agreement [Member] \| BDI Holdings [Member] \| Maximum [Member]
Collaborative Arrangement, Revenue Sharing, Percentage			75.00%	75.00%
Research Services Agreement [Member] \| VLPBio Member
Collaborative Arrangement, Equity Interest Acquired			3.30%	3.30%