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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Stock-based compensation	$ 446,120	$ 436,613	$ 867,191	$ 863,552
General and Administrative Expense [Member]
Stock-based compensation	401,133	390,701	778,185	770,953
Research and Development Expense [Member]
Stock-based compensation	$ 44,987	$ 45,912	$ 89,006	$ 92,599

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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