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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Stock-based compensation | $ 457,209 | $ 400,681 | $ 1,324,400 | $ 1,264,233
General and Administrative Expense [Member] |  |  |  |
Stock-based compensation | 405,383 | 354,264 | 1,183,568 | 1,125,217
Research and Development Expense [Member] |  |  |  |
Stock-based compensation | $ 51,826 | $ 46,417 | $ 140,832 | $ 139,016

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