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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Stock-based compensation	$ 457,209	$ 400,681	$ 1,324,400	$ 1,264,233
General and Administrative Expense [Member]
Stock-based compensation	405,383	354,264	1,183,568	1,125,217
Research and Development Expense [Member]
Stock-based compensation	$ 51,826	$ 46,417	$ 140,832	$ 139,016

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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