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v3.22.1

Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Cash flows from operating activities |  |
Net loss | $ (2,491,665) | $ (3,294,949)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 453,791 | 421,071
Amortization of held-to-maturity securities, net | 13,446 | 63,951
Foreign currency exchange loss (gain), net | (10,247) | 28,272
Changes in operating assets and liabilities: |  |
Interest receivable | 65,481 | (44,954)
Accounts receivable | (241,002) | (131,800)
Prepaid expenses and other current assets | 131,299 | 64,297
Accounts payable | (679,918) | 480,455
Accrued expenses | (176,396) | (212,088)
Deferred research and development obligation | 163,859 | 719,232
Deferred license revenue | (79,031) | 0
Net cash used in operating activities | (2,850,383) | (1,906,513)
Cash flows from investing activities |  |
Purchases of held-to-maturity investment securities | (5,020,850) | (11,283,940)
Proceeds from maturities of investment securities | 4,500,000 | 5,500,000
Net cash used in investing activities | (520,850) | (5,783,940)
Cash flows from financing activities |  |
Proceeds from exercise of options | 42,350 | 115,800
Net cash provided by financing activities | 42,350 | 115,800
Effect of exchange rate changes on cash | (568) | (6,834)
Net decrease in cash and cash equivalents | (3,329,451) | (7,581,487)
Cash and cash equivalents at beginning of period | 15,748,480 | 20,637,045
Cash and cash equivalents at end of period | $ 12,419,029 | $ 13,055,558

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