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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Stock-based compensation | $ 454,500 | $ 446,120 | $ 908,291 | $ 867,191
General and Administrative Expense [Member] |  |  |  |
Stock-based compensation | 389,885 | 401,133 | 778,548 | 778,185
Research and Development Expense [Member] |  |  |  |
Stock-based compensation | $ 64,615 | $ 44,987 | $ 129,743 | $ 89,006

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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