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Note 5 - Share-based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Notes Tables

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Risk-Free interest rate			1.40% - 3.24%
Expected dividend yield			—%
Expected stock price volatility			61.30 - 61.58%
Expected life of options (in years)			5.50 - 6.25

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

										Weighted-Average
						Weighted-Average				Remaining Contractual				Aggregate Intrinsic
		Shares				Exercise Price				Term (Years)				Value
Outstanding at December 31, 2021			4,774,215			$	3.04				6.14			$	8,413,444
Granted (1)			865,825				4.43
Exercised			(35,000	)			1.21
Expired			(30,000	)			6.87
Canceled			(75,000	)			4.81
Outstanding at June 30, 2022			5,500,040			$	3.23				6.20			$	4,113,421
Exercisable at June 30, 2022			4,070,223			$	2.79				5.24			$	3,937,808

Share-Based Payment Arrangement, Activity [Table Text Block]

		Three Months Ended June 30,								Six Months Ended June 30,
		2022				2021				2022				2021
General and administrative		$	389,885			$	401,133			$	778,548			$	778,185
Research and development			64,615				44,987				129,743				89,006
Total		$	454,500			$	446,120			$	908,291			$	867,191

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- Definition

Tabular disclosure of activity for award under share-based payment arrangement. Includes, but is not limited to, outstanding award at beginning and end of year, granted, exercised, forfeited, and weighted-average grant date fair value.

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