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Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual)	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 USD ($) shares	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 USD ($) shares	Dec. 31, 2021 USD ($)
Number of Operating Segments			1
Revenue from Contract with Customer, Excluding Assessed Tax	$ 658,553	$ 937,092	$ 1,306,980	$ 1,397,612
Accounts Receivable, Allowance for Credit Loss, Ending Balance	0		0		$ 0
Deferred Tax Assets, Net, Total	$ 15,700,000		$ 15,700,000		$ 13,100,000
Deferred Tax Assets, Valuation Allowance Coverage, Percent			100.00%		100.00%
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares	5,605,040	4,799,215	5,605,040	4,799,215
Customer Concentration Risk [Member] | Revenue Benchmark [Member]
Concentration Risk, Number of Customers	7	11	11	13
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member]
Concentration Risk, Number of Customers	4	6	5	7
Revenue from Contract with Customer, Excluding Assessed Tax	$ 239,000	$ 797,000	$ 375,000	$ 1,121,000
Concentration Risk, Percentage	38.90%	85.10%	32.70%	80.20%
Customer Concentration Risk [Member] | Accounts Receivable [Member]
Concentration Risk, Number of Customers			9		8
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member]
Concentration Risk, Number of Customers			5		4
Concentration Risk, Percentage			15.60%		56.40%
Accounts Receivable, after Allowance for Credit Loss, Total	$ 179,000		$ 179,000		$ 157,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member]
Concentration Risk, Number of Customers	2	2
Concentration Risk, Number of Suppliers			2	3
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Two CROs [Member]
Concentration Risk, Percentage	96.20%	95.80%	96.50%
Research Services Purchased	$ 1,299,000	$ 2,622,000	$ 2,794,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member]
Concentration Risk, Percentage				96.80%
Research Services Purchased				$ 4,639,000
Supplier Concentration Risk [Member] | Accounts Payable [Member]
Concentration Risk, Number of Suppliers			2		2
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Two CROs [Member]
Concentration Risk, Percentage			79.70%		84.80%
Accounts Payable, Total	$ 873,000		$ 873,000		$ 1,312,000

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