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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Stock-based compensation | $ 499,919 | $ 457,209 | $ 1,408,210 | $ 1,324,400
General and Administrative Expense [Member] |  |  |  |
Stock-based compensation | 441,279 | 405,383 | 1,219,827 | 1,183,568
Research and Development Expense [Member] |  |  |  |
Stock-based compensation | $ 58,640 | $ 51,826 | $ 188,383 | $ 140,832

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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