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Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual)	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2022 USD ($) shares	Sep. 30, 2021 USD ($) shares	Sep. 30, 2022 USD ($) shares	Sep. 30, 2021 USD ($) shares	Dec. 31, 2021 USD ($)
Number of Operating Segments			1
Revenue from Contract with Customer, Excluding Assessed Tax	$ 879,597	$ 692,929	$ 2,186,577	$ 2,090,541
Accounts Receivable, Allowance for Credit Loss, Ending Balance	0		0		$ 0
Deferred Tax Assets, Net, Total	$ 15,700,000		$ 15,700,000		$ 13,000,000.0
Deferred Tax Assets, Valuation Allowance Coverage, Percent			100.00%		100.00%
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares	5,281,097	4,824,215	5,281,097	4,824,215
Customer Concentration Risk [Member] | Revenue Benchmark [Member]
Concentration Risk, Number of Customers	8	8	13	13
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member]
Concentration Risk, Number of Customers	4	5	6	7
Revenue from Contract with Customer, Excluding Assessed Tax	$ 133,000	$ 478,000	$ 509,000	$ 1,599,000
Concentration Risk, Percentage	16.00%	69.10%	25.60%	76.50%
Customer Concentration Risk [Member] | Accounts Receivable [Member]
Concentration Risk, Number of Customers			4		8
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member]
Concentration Risk, Number of Customers			2		4
Revenue from Contract with Customer, Excluding Assessed Tax			$ 43,000
Concentration Risk, Percentage			17.80%		56.40%
Accounts Receivable, after Allowance for Credit Loss, Total					$ 157,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member]
Concentration Risk, Number of Customers	3	2
Concentration Risk, Number of Suppliers			3	3
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Two CROs [Member]
Concentration Risk, Percentage	99.50%	97.20%	97.40%	96.90%
Research Services Purchased	$ 1,352,000	$ 1,982,000	$ 4,146,000	$ 6,621,000
Supplier Concentration Risk [Member] | Accounts Payable [Member]
Concentration Risk, Number of Suppliers			3		2
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Two CROs [Member]
Concentration Risk, Percentage			91.90%		84.80%
Accounts Payable, Total	$ 714,000		$ 714,000		$ 1,312,000

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