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Note 5 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Stock-based compensation	$ 499,919	$ 457,209	$ 1,408,210	$ 1,324,400
General and Administrative Expense [Member]
Stock-based compensation	441,279	405,383	1,219,827	1,183,568
Research and Development Expense [Member]
Stock-based compensation	$ 58,640	$ 51,826	$ 188,383	$ 140,832

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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