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Note 6 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021
Stock-based compensation | $ 1,888,944 | $ 1,784,102
General and Administrative Expense [Member] |  |
Stock-based compensation | 1,661,025 | 1,571,328
Research and Development Expense [Member] |  |
Stock-based compensation | $ 227,919 | $ 212,774

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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