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Note 3 - Research and Collaboration Agreements, Sublicense Agreements, and Investments in Privately Held Companies (Details Textual) |  |  |  |  |  |  | 6 Months Ended | 12 Months Ended |  |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 31, 2023 USD ($) | Jan. 18, 2023 USD ($) | Jan. 03, 2023 USD ($) | May 10, 2022 USD ($) | Jun. 24, 2020 | Jun. 30, 2017 USD ($) | Jun. 30, 2017 EUR (€) | Dec. 31, 2022 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Feb. 10, 2022 | Dec. 16, 2021 USD ($) | Dec. 16, 2021 EUR (€) | Jul. 26, 2021 | Jul. 08, 2021 shares | Dec. 31, 2020 USD ($) | Dec. 01, 2020 | Apr. 26, 2019
Collaborative Arrangement, Payment for Research and Development Agreement |  |  |  |  |  | $ 1,100,000 | € 1,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  |  |  |  |  | $ 2,930,303 | $ 2,403,831 |  |  |  |  |  |  |  |
Number of Performance Obligations |  |  |  |  |  |  |  |  |  |  |  | 2 | 2 |  |  |  |  |
Upfront Payment Payable |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |
Research and Development Expense, Related Party |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |
Deferred License Revenue, Net of Current Portion |  |  |  |  |  |  |  | $ 176,471 | 176,471 | 352,941 |  |  |  |  |  |  |  |
Accounts Receivable, after Allowance for Credit Loss, Current, Total |  |  |  |  |  |  |  | 330,001 | 330,001 | 277,831 |  |  |  |  |  |  |  |
Cost of Goods and Services Sold, Total |  |  |  |  |  |  |  |  | 2,123,193 | 1,944,438 |  |  |  |  |  |  |  |
Research and Development Expense, Total |  |  |  |  |  |  |  |  | 4,501,365 | 8,392,370 |  |  |  |  |  |  |  |
Deferred License Revenue, Current |  |  |  |  |  |  |  | 176,471 | 176,471 | 147,059 |  |  |  |  |  |  |  |
BDI Holdings [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Sales of Business, Affiliate and Productive Assets |  |  |  |  |  |  |  |  |  | 1,600,000 |  |  |  |  |  |  |  |
Research Services Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement, Payment for Research and Development Agreement | € |  |  |  |  |  |  | € 1,000,000 |  |  |  |  |  |  |  |  |  |  |
Alphazyme [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of Stock, Percentage of Ownership after Transaction |  |  |  |  | 2.50% |  |  |  |  |  |  |  |  |  |  |  |  |
Equity Securities without Readily Determinable Fair Value, Amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 284,709 |  |
Alphazyme [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Sale, Maturity and Collection of Investments, Total | $ 1,270,000 | $ 1,270,000 | $ 1.27 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novovet [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity Method Investment, Ownership Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20.00%
Unbilled Revenues [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts Receivable, after Allowance for Credit Loss, Current, Total |  |  |  |  |  |  |  | 214,532 | 214,532 | 176,656 |  |  |  |  |  |  |  |
ID Biologics Inc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Investment Owned, Balance, Shares (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 129,661 |  |  |
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.37% |  |  |
Cost of Goods and Services Sold, Total |  |  |  |  |  |  |  |  | 109,000 | 194,000 |  |  |  |  |  |  |  |
Alphazyme [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ownership Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1.99% |
BDI Holdings [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ownership Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  | 16.10% |  |  |  |
Research and Development Expense, Total |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
BDI Holdings [Member] | Research Services Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement, Equity Interest Acquired |  |  |  |  |  | 16.10% | 16.10% |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement, Minimum Obligation For Research and Development | € |  |  |  |  |  |  | € 936,000 |  |  |  |  |  |  |  |  |  |  |
VLPBio Member |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ownership Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.30% |  |  |  |
VLPBio Member | Research Services Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement, Equity Interest Acquired |  |  |  |  |  | 3.30% | 3.30% |  |  |  |  |  |  |  |  |  |  |
Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  |  |  |  |  | 2,683,244 | 2,403,831 |  |  |  |  |  |  |  |
A Global Food Ingredient Company [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement, Payment for Research and Development Agreement |  |  |  | $ 4,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement, Duration Of Agreement (Year) |  |  |  | 2 years |  |  |  |  |  |  |  |  |  |  |  |  |  |
A Global Food Ingredient Company [Member] | Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  |  |  |  |  | 790,000 |  |  |  |  |  |  |  |  |
Abic Biolgical Latories Ltd. [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Performance Obligations |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |
Janssen Pharmaceutical Companies [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Upfront Payment, Received |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |
Deferred License Revenue, Net of Current Portion |  |  |  |  |  |  |  | 176,000 | 176,000 |  |  |  |  |  |  |  |  |
Accounts Receivable, after Allowance for Credit Loss, Current, Total |  |  |  |  |  |  |  | 121,000 | 121,000 | 0 |  |  |  |  |  |  |  |
Deferred License Revenue, Current |  |  |  |  |  |  |  | 176,000 | 176,000 |  |  |  |  |  |  |  |  |
Janssen Pharmaceutical Companies [Member] | Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  |  |  |  |  |  |  | 539,000 | 0 |  |  |  |  |  |  |  |
Contract with Customer, Asset, after Allowance for Credit Loss, Total | € |  |  |  |  |  |  |  |  |  |  |  |  | € 1,600,000 |  |  |  |  |
ID Biologics Inc [Member] | Unbilled Revenues [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accounts Receivable, after Allowance for Credit Loss, Current, Total |  |  |  |  |  |  |  | $ 0 | $ 0 | $ 27,000 |  |  |  |  |  |  |  |

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