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Note 4 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Notes Tables |
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] |
|  | Years Ended December 31, |
|  | 2022 |  |  | 2021 |
U.S. operations |  | $ | (9,828,427 | ) |  | $ | (13,115,869 | )
Foreign operations |  |  | 93,169 |  |  |  | 45,618 |
Total loss before provision for income taxes |  | $ | (9,735,258 | ) |  | $ | (13,070,251 | )
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
|  | Years Ended December 31, |
|  | 2022 |  |  | 2021 |
Tax at U.S. statutory rate |  |  | (21.00 | )% |  |  | (21.00 | )%
State taxes, net of federal benefit |  |  | (4.35 | ) |  |  | (4.52 | )
Non-deductible items |  |  | — |  |  |  | (0.84 | )
Change in valuation allowance |  |  | 24.77 |  |  |  | 28.09 |
True-up adjustment |  |  | 0.34 |  |  |  | 0.06 |
Foreign operations |  |  | 0.24 |  |  |  | 0.09 |
Change in tax rate |  |  | — |  |  |  | (1.88 | )
Other |  |  | — |  |  |  | — |
Effective income tax rate |  |  | — | % |  |  | — | %
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | December 31, |
|  | 2022 |  |  | 2021 |
Stock option expense |  | $ | 1,341,900 |  |  | $ | 947,400 |
NOL carryforward |  |  | 11,524,900 |  |  |  | 10,509,900 |
Research and development credits |  |  | 1,623,100 |  |  |  | 1,656,500 |
Section 174 - R&D expenses |  |  | 1,046,400 |  |  |  | — |
Unrealized gain from investment in Alphazyme |  |  | — |  |  |  | (72,100 | )
Other |  |  | (78,200 | ) |  |  | (6,100 | )
Deferred tax asset, net of deferred tax liabilities |  |  | 15,458,100 |  |  |  | 13,035,600 |
Valuation allowance |  |  | (15,458,100 | ) |  |  | (13,035,600 | )
Net deferred tax asset |  | $ | — |  |  | $ | — |

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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