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Note 1 - Organization and Summary of Significant Accounting Policies (Tables)
12 Months Ended
Dec. 31, 2022
Notes Tables  
Schedule of Accounts, Notes, Loans and Financing Receivable [Table Text Block]
  

December 31,

 
  

2022

  

2021

 

Billed receivable

 $115,469  $101,175 

Unbilled receivable

  214,532   176,656 
  $330,001  $277,831 
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
  

December 31,

 
  

2022

  

2021

 

Prepaid insurance

 $265,429  $326,712 

Prepaid expenses - various

  124,273   45,839 

Prepaid taxes

  2,534   3,279 
  $392,236  $375,830 
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
  

December 31,

 
  

2022

  

2021

 

Research and development expenses

 $1,067,958  $1,363,889 

Legal expenses

  56,514   27,675 

Other

  151,841   156,389 
  $1,276,313  $1,547,953 
Schedule of Accrued Liabilities [Table Text Block]
  

December 31,

 
  

2022

  

2021

 

Employee wages and benefits

 $580,264  $405,758 

Research and development expenses

  343,457   194,250 

Other

  31,360   109,552 
  $955,081  $709,560 
Schedule of Research and Development Costs [Table Text Block]
  

Years Ended December 31,

 
  

2022

  

2021

 

Outside contracted services

 $3,707,269  $7,607,035 

Personnel related costs

  743,051   773,823 

Facilities, overhead and other

  51,045   11,512 
  $4,501,365  $8,392,370