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Note 1 - Organization and Summary of Significant Accounting Policies - Research and Development Costs (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Outside contracted services $ 3,707,269 $ 7,607,035
Personnel related costs 743,051 773,823
Facilities, overhead and other 51,045 11,512
Research And Development Expense, Including Related Party $ 4,501,365 $ 8,392,370