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Note 3 - Research and Collaboration Agreements, Sublicense Agreements, and Investments in Privately Held Companies (Details Textual)								6 Months Ended	12 Months Ended
	Jan. 31, 2023 USD ($)	Jan. 18, 2023 USD ($)	Jan. 03, 2023 USD ($)	May 10, 2022 USD ($)	Jun. 24, 2020	Jun. 30, 2017 USD ($)	Jun. 30, 2017 EUR (€)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Feb. 10, 2022	Dec. 16, 2021 USD ($)	Dec. 16, 2021 EUR (€)	Jul. 26, 2021	Jul. 08, 2021 shares	Dec. 31, 2020 USD ($)	Dec. 01, 2020	Apr. 26, 2019
Collaborative Arrangement, Payment for Research and Development Agreement						$ 1,100,000	€ 1,000,000.0
Revenue from Contract with Customer, Excluding Assessed Tax									$ 2,930,303	$ 2,403,831
Number of Performance Obligations												2	2
Upfront Payment Payable												$ 500,000
Research and Development Expense, Related Party									0
Deferred License Revenue, Net of Current Portion								$ 176,471	176,471	352,941
Accounts Receivable, after Allowance for Credit Loss, Current, Total								330,001	330,001	277,831
Cost of Goods and Services Sold, Total									2,123,193	1,944,438
Research and Development Expense, Total									4,501,365	8,392,370
Deferred License Revenue, Current								176,471	176,471	147,059
BDI Holdings [Member]
Proceeds from Sales of Business, Affiliate and Productive Assets										1,600,000
Research Services Agreement [Member]
Collaborative Arrangement, Payment for Research and Development Agreement | €							€ 1,000,000
Alphazyme [Member]
Sale of Stock, Percentage of Ownership after Transaction					2.50%
Equity Securities without Readily Determinable Fair Value, Amount																$ 284,709
Alphazyme [Member] | Subsequent Event [Member]
Proceeds from Sale, Maturity and Collection of Investments, Total	$ 1,270,000	$ 1,270,000	$ 1.27
Novovet [Member]
Equity Method Investment, Ownership Percentage																		20.00%
Unbilled Revenues [Member]
Accounts Receivable, after Allowance for Credit Loss, Current, Total								214,532	214,532	176,656
ID Biologics Inc [Member]
Investment Owned, Balance, Shares (in shares) | shares															129,661
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners															0.37%
Cost of Goods and Services Sold, Total									109,000	194,000
Alphazyme [Member]
Ownership Percentage																	1.99%
BDI Holdings [Member]
Ownership Percentage														16.10%
Research and Development Expense, Total								0
BDI Holdings [Member] | Research Services Agreement [Member]
Collaborative Arrangement, Equity Interest Acquired						16.10%	16.10%
Collaborative Arrangement, Minimum Obligation For Research and Development | €							€ 936,000
VLPBio Member
Ownership Percentage														3.30%
VLPBio Member | Research Services Agreement [Member]
Collaborative Arrangement, Equity Interest Acquired						3.30%	3.30%
Research and Development [Member]
Revenue from Contract with Customer, Excluding Assessed Tax									2,683,244	2,403,831
A Global Food Ingredient Company [Member]
Collaborative Arrangement, Payment for Research and Development Agreement				$ 4,100,000
Collaborative Arrangement, Duration Of Agreement (Year)				2 years
A Global Food Ingredient Company [Member] | Research and Development [Member]
Revenue from Contract with Customer, Excluding Assessed Tax									790,000
Abic Biolgical Latories Ltd. [Member]
Number of Performance Obligations											2
Janssen Pharmaceutical Companies [Member]
Non-refundable Upfront Payment, Received												$ 500,000
Deferred License Revenue, Net of Current Portion								176,000	176,000
Accounts Receivable, after Allowance for Credit Loss, Current, Total								121,000	121,000	0
Deferred License Revenue, Current								176,000	176,000
Janssen Pharmaceutical Companies [Member] | Research and Development [Member]
Revenue from Contract with Customer, Excluding Assessed Tax									539,000	0
Contract with Customer, Asset, after Allowance for Credit Loss, Total | €													€ 1,600,000
ID Biologics Inc [Member] | Unbilled Revenues [Member]
Accounts Receivable, after Allowance for Credit Loss, Current, Total								$ 0	$ 0	$ 27,000

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