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Note 6 - Share-based Compensation - Noncash Stock Option Compensation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Stock-based compensation	$ 1,888,944	$ 1,784,102
General and Administrative Expense [Member]
Stock-based compensation	1,661,025	1,571,328
Research and Development Expense [Member]
Stock-based compensation	$ 227,919	$ 212,774

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

+ Details

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X

- Details

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