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Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities
Net loss	$ (9,735,258)	$ (13,070,251)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	1,888,944	1,784,102
Amortization of held-to-maturity securities, net	33,790	329,612
Gain on investment in BDI	0	(1,605,532)
Foreign currency exchange loss	49,918	96,893
Changes in operating assets and liabilities:
Interest receivable	36,090	17,872
Accounts receivable	(83,265)	(31,792)
Prepaid expenses and other current assets	(13,925)	(95,366)
Accounts payable	(248,128)	549,562
Accrued expenses	245,521	219,824
Deferred license revenue	(147,058)	500,000
Deferred research and development obligations	(110,404)	28,131
Net cash used in operating activities	(8,083,775)	(11,276,945)
Cash flows from investing activities
Purchases of held-to-maturity investment securities	(9,869,280)	(11,283,940)
Proceeds from maturities of investment securities	7,500,000	14,900,000
Proceeds from the sale of investment in BDI	0	1,605,532
Net cash (used in) provided by investing activities	(2,369,280)	5,221,592
Cash flows from financing activities
Proceeds from exercise of options	543,591	1,230,050
Net cash provided by financing activities	543,591	1,230,050
Effect of exchange rate changes on cash	(44,744)	(63,262)
Net decrease in cash and cash equivalents	(9,954,208)	(4,888,565)
Cash and cash equivalents at beginning of period	15,748,480	20,637,045
Cash and cash equivalents at end of period	$ 5,794,272	$ 15,748,480

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