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Note 3 - Research and Collaboration Agreements, Sublicense Agreements, and Investments in Privately Held Companies (Details Textual) - USD ($) | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Oct. 05, 2023 | Dec. 01, 2020
Revenue from Contract with Customer, Excluding Assessed Tax | $ 2,898,806 | $ 2,930,303 |  |
Alphazyme [Member] |  |  |  |
Proceeds from Sale, Maturity and Collection of Investments | 1,300,000 |  |  |
Alphazyme [Member] |  |  |  |
Ownership Percentage |  |  |  | 1.99%
Research and Development [Member] |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax | 2,545,865 | 2,683,244 |  |
Inzymes Agreement APS [Member] |  |  |  |
Non-refundable Upfront Payment, Received | 600,000 |  | $ 600,000 |
Revenue from Contract with Customer, Excluding Assessed Tax | 110,000 |  |  |
A Global Food Ingredient Company [Member] | Research and Development [Member] | Purchase Provision Terms [Member] |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax | 631,000 | 790,000 |  |
Janssen Pharmaceutical Companies [Member] |  |  |  |
Deferred License Revenue | 353,000 | 176,000 |  |
Accounts Receivable, after Allowance for Credit Loss | 145,000 | 121,000 |  |
Janssen Pharmaceutical Companies [Member] | Research and Development [Member] |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax | $ 520,000 | $ 539,000 |  |

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