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v3.24.1

Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual) |  | 12 Months Ended | 36 Months Ended |  |
--- | --- | --- | --- | --- | ---
Mar. 08, 2024 USD ($) $ / shares | Dec. 31, 2023 USD ($) ft² shares | Dec. 31, 2022 USD ($) shares | Aug. 31, 2026 | Oct. 05, 2023 USD ($) | Sep. 01, 2023
Number of Operating Segments |  | 1 |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 2,898,806 | $ 2,930,303 |  |  |
Accounts Receivable, Allowance for Credit Loss |  | 0 | 0 |  |  |
Operating Lease, Expense |  | 72,000 | 58,000 |  |  |
Operating Lease, Liability |  | 136,929 | 0 |  |  |
Lessee, Operating Lease, Liability, Undiscounted Excess Amount |  | 16,770 |  |  |  |
Operating Lease, Right-of-Use Asset |  | $ 141,439 | 0 |  |  |
Operating Lease, Weighted Average Remaining Lease Term (Year) |  | 2 years 8 months 12 days |  |  |  |
Operating Lease, Weighted Average Discount Rate, Percent |  | 8.80% |  |  |  |
Other Income |  | $ 1,018,000 | $ 250,000 |  |  |
Share-Based Payment Arrangement [Member] |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  | 5,469,247 | 5,031,097 |  |  |
The 1044 N Lease [Member] |  |  |  |  |  |
Area of Real Estate Property (Square Foot) | ft² |  | 1,719 |  |  |  |
Lessee Operating Lease Yearly Percentage Increase |  |  |  | 3.00% |  |
Lessee, Operating Lease, Term of Contract (Year) |  |  |  |  |  | 3 years
Lessee Operating Lease Additional Number of Renewal Terms |  |  |  |  |  | 2
Lessee, Operating Lease, Renewal Term (Year) |  |  |  |  |  | 1 year
Customer Concentration Risk [Member] | Revenue Benchmark [Member] |  |  |  |  |  |
Concentration Risk, Number of Customers |  | 16 | 14 |  |  |
Concentration Risk, Significant Customers |  | 2 | 3 |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member] |  |  |  |  |  |
Concentration Risk, Number of Customers |  | 6 |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 537,000 | $ 586,000 |  |  |
Concentration Risk, Percentage |  | 21.10% | 21.80% |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Two Significant Customers [Member] |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 1,150,000 |  |  |  |
Concentration Risk, Percentage |  | 45.20% |  |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Three Significant Customers [Member] |  |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | $ 1,811,000 |  |  |
Concentration Risk, Percentage |  |  | 67.50% |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] |  |  |  |  |  |
Concentration Risk, Number of Customers |  | 13 | 6 |  |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member] |  |  |  |  |  |
Concentration Risk, Number of Customers |  | 6 | 4 |  |  |
Concentration Risk, Percentage |  | 45.60% | 27.40% |  |  |
Accounts Receivable, after Allowance for Credit Loss |  | $ 213,000 | $ 91,000 |  |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  | 3 | 3 |  |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  | 96.00% | 97.90% |  |  |
Research Services Purchased |  | $ 4,644,000 | $ 5,575,000 |  |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] |  |  |  |  |  |
Concentration Risk, Number of Suppliers |  | 3 | 3 |  |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  | 94.40% | 79.70% |  |  |
Accounts Payable |  | $ 620,000 | $ 1,018,000 |  |  |
Subsequent Event [Member] | Senior Secured 2024 Notes [Member] |  |  |  |  |  |
Debt Instrument, Face Amount | $ 6,000,000 |  |  |  |  |
Debt Instrument, Interest Rate, Stated Percentage | 8.00% |  |  |  |  |
Debt Instrument, Convertible, Conversion Price (in dollars per share) | $ / shares | $ 1.79 |  |  |  |  |
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger | 125.00% |  |  |  |  |
Inzymes Agreement APS [Member] |  |  |  |  |  |
Non-refundable Upfront Payment, Received |  | 600,000 |  |  | $ 600,000 |
Revenue from Contract with Customer, Excluding Assessed Tax |  | 110,000 |  |  |  |
Alphazyme [Member] |  |  |  |  |  |
Proceeds from Sale, Maturity and Collection of Investments |  | $ 1,300,000 |  |  |  |

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