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v3.24.1.1.u2

Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual) |  | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Mar. 08, 2024 USD ($) $ / shares | Mar. 31, 2024 USD ($) shares | Mar. 31, 2023 USD ($) shares | Dec. 31, 2023 USD ($) | Jan. 01, 2024 USD ($)
Number of Operating Segments |  | 1 |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 334,617 | $ 978,052 |  |
Accounts Receivable, Allowance for Credit Loss |  |  |  | $ 0 | $ 0
Deferred Tax Assets, Net |  | $ 17,700,000 |  | $ 16,400,000 |
Deferred Tax Assets, Valuation Allowance Coverage, Percent |  | 100.00% |  | 100.00% |
Share-Based Payment Arrangement [Member] |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  | 6,100,857 | 5,581,991 |  |
Restricted Stock Units (RSUs) [Member] |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  | 191,510 | 163,044 |  |
Share-Based Payment Arrangement, Option [Member] |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares |  | 5,909,347 | 5,418,947 |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] |  |  |  |  |
Concentration Risk, Number of Customers |  | 10 | 7 |  |
Concentration Risk, Significant Customers |  | 4 | 3 |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member] |  |  |  |  |
Concentration Risk, Number of Customers |  | 8 | 1 |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 274,000 | $ 154,000 |  |
Concentration Risk, Percentage |  | 81.80% | 16.50% |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Four Significant Customers [Member] |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 225,000 |  |  |
Concentration Risk, Percentage |  | 67.20% |  |  |
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Three Significant Customers [Member] |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  |  | $ 626,000 |  |
Concentration Risk, Percentage |  |  | 67.00% |  |
Customer Concentration Risk [Member] | Accounts Receivable [Member] |  |  |  |  |
Concentration Risk, Number of Customers |  | 10 |  | 13 |
Concentration Risk, Significant Customers |  | 6 |  | 2 |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member] |  |  |  |  |
Concentration Risk, Number of Customers |  | 7 |  | 6 |
Concentration Risk, Percentage |  | 71.00% |  | 45.60% |
Accounts Receivable, after Allowance for Credit Loss |  | $ 175,000 |  | $ 213,000 |
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Six Significant Customers [Member] |  |  |  |  |
Revenue from Contract with Customer, Excluding Assessed Tax |  | $ 208,000 |  | $ 1,150,000 |
Concentration Risk, Percentage |  | 84.60% |  | 45.20% |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] |  |  |  |  |
Concentration Risk, Number of Suppliers |  | 3 | 3 |  |
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member] |  |  |  |  |
Concentration Risk, Percentage |  | 81.40% | 95.00% |  |
Research Services Purchased |  | $ 359,000 | $ 1,076,000 |  |
Supplier Concentration Risk [Member] | Accounts Payable [Member] |  |  |  |  |
Concentration Risk, Number of Suppliers |  | 3 |  | 3 |
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member] |  |  |  |  |
Concentration Risk, Percentage |  | 16.50% |  | 94.40% |
Accounts Payable |  | $ 109,000 |  | $ 620,000 |
Senior Secured 2024 Notes [Member] |  |  |  |  |
Debt Instrument, Face Amount | $ 6,000,000 |  |  |  |
Debt Instrument, Interest Rate, Stated Percentage | 8.00% |  |  |  |
Proceeds from Issuance of Senior Long-Term Debt | $ 5,824,000 |  |  |  |
Debt Instrument, Convertible, Conversion Price (in dollars per share) | $ / shares | $ 1.79 |  |  |  |
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger | 125.00% |  |  |  |

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