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Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual)		3 Months Ended		12 Months Ended
	Mar. 08, 2024 USD ($) $ / shares	Mar. 31, 2024 USD ($) shares	Mar. 31, 2023 USD ($) shares	Dec. 31, 2023 USD ($)	Jan. 01, 2024 USD ($)
Number of Operating Segments		1
Revenue from Contract with Customer, Excluding Assessed Tax		$ 334,617	$ 978,052
Accounts Receivable, Allowance for Credit Loss				$ 0	$ 0
Deferred Tax Assets, Net		$ 17,700,000		$ 16,400,000
Deferred Tax Assets, Valuation Allowance Coverage, Percent		100.00%		100.00%
Share-Based Payment Arrangement [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares		6,100,857	5,581,991
Restricted Stock Units (RSUs) [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares		191,510	163,044
Share-Based Payment Arrangement, Option [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares		5,909,347	5,418,947
Customer Concentration Risk [Member] | Revenue Benchmark [Member]
Concentration Risk, Number of Customers		10	7
Concentration Risk, Significant Customers		4	3
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member]
Concentration Risk, Number of Customers		8	1
Revenue from Contract with Customer, Excluding Assessed Tax		$ 274,000	$ 154,000
Concentration Risk, Percentage		81.80%	16.50%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Four Significant Customers [Member]
Revenue from Contract with Customer, Excluding Assessed Tax		$ 225,000
Concentration Risk, Percentage		67.20%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Three Significant Customers [Member]
Revenue from Contract with Customer, Excluding Assessed Tax			$ 626,000
Concentration Risk, Percentage			67.00%
Customer Concentration Risk [Member] | Accounts Receivable [Member]
Concentration Risk, Number of Customers		10		13
Concentration Risk, Significant Customers		6		2
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member]
Concentration Risk, Number of Customers		7		6
Concentration Risk, Percentage		71.00%		45.60%
Accounts Receivable, after Allowance for Credit Loss		$ 175,000		$ 213,000
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Six Significant Customers [Member]
Revenue from Contract with Customer, Excluding Assessed Tax		$ 208,000		$ 1,150,000
Concentration Risk, Percentage		84.60%		45.20%
Supplier Concentration Risk [Member] | Contract Research Organizations [Member]
Concentration Risk, Number of Suppliers		3	3
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member]
Concentration Risk, Percentage		81.40%	95.00%
Research Services Purchased		$ 359,000	$ 1,076,000
Supplier Concentration Risk [Member] | Accounts Payable [Member]
Concentration Risk, Number of Suppliers		3		3
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member]
Concentration Risk, Percentage		16.50%		94.40%
Accounts Payable		$ 109,000		$ 620,000
Senior Secured 2024 Notes [Member]
Debt Instrument, Face Amount	$ 6,000,000
Debt Instrument, Interest Rate, Stated Percentage	8.00%
Proceeds from Issuance of Senior Long-Term Debt	$ 5,824,000
Debt Instrument, Convertible, Conversion Price (in dollars per share) | $ / shares	$ 1.79
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger	125.00%

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